The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that
it displays greater diversity in activation mechanisms and selectivities than any other group …

Insects such as the fruit fly, Drosophila melanogaster, rely on contact chemosensation to
detect nutrient-rich foods, to avoid consuming toxic chemicals, and to select mates and …

Below a certain level, table salt (NaCl) is beneficial for animals, whereas excessive salt is
harmful. However, it remains unclear how low- and high-salt taste perceptions are differentially …

Recent studies suggest that the fly uses the inositol lipid signaling system for visual excitation
and that the Drosophila transient receptor potential (trp) mutation disrupts this process …

The transient receptor potential (TRP) protein superfamily consists of a diverse group of cation
channels that bear structural similarities to Drosophila TRP. TRP channels play important …

TRP cation channels display an extraordinary assortment of selectivities and activation
mechanisms, some of which represent previously unrecognized modes for regulating ion …

The TRP superfamily includes a diversity of non-voltagegated cation channels that vary
significantly in their selectivity and mode of activation. Nevertheless, members of the TRP …

In many vertebrate and invertebrate cells, inositol 1,4,5-trisphospate production induces a
biphasic Ca2+ signal. Mobilization of Ca2+ from internal stores drives the initial burst. The …

We present evidence for a specific role of p53 in the mitochondria-associated cellular
dysfunction and behavioral abnormalities of Huntington's disease (HD). Mutant huntingtin (mHtt) …

The transient receptor potential (TRP1) ion channels are named after the role of the channels
in Drosophila phototransduction. The mammalian genes are encoded by at least 28 …