[PDF][PDF] BLA to vHPC inputs modulate anxiety-related behaviors

…, A Beyeler, C Seo, CA Leppla, CP Wildes… - Neuron, 2013 - cell.com
The basolateral amygdala (BLA) and ventral hippocampus (vHPC) have both been implicated
in mediating anxiety-related behaviors, but the functional contribution of BLA inputs to the …

[PDF][PDF] Divergent routing of positive and negative information from the amygdala during memory retrieval

…, GG Calhoon, GF Conyers, R Luck, CP Wildes… - Neuron, 2016 - cell.com
Although the basolateral amygdala (BLA) is known to play a critical role in the formation of
memories of both positive and negative valence, the coding and routing of valence-related …

[PDF][PDF] Decoding neural circuits that control compulsive sucrose seeking

…, CA Leppla, R Wichmann, R Neve, CP Wildes… - Cell, 2015 - cell.com
The lateral hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked
to reward processing, but the computations within the LH-VTA loop that give rise to specific …

[PDF][PDF] Dorsal raphe dopamine neurons represent the experience of social isolation

…, EM Izadmehr, RE Thomas, GD Lacy, CP Wildes… - Cell, 2016 - cell.com
The motivation to seek social contact may arise from either positive or negative emotional
states, as social interaction can be rewarding and social isolation can be aversive. While …

[PDF][PDF] Organization of valence-encoding and projection-defined neurons in the basolateral amygdala

…, M Silvestre, C Lévêque, P Namburi, CP Wildes… - Cell reports, 2018 - cell.com
The basolateral amygdala (BLA) mediates associative learning for both fear and reward.
Accumulating evidence supports the notion that different BLA projections distinctly alter …

Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli

…, EY Kimchi, A Beyeler, R Wichmann, CP Wildes… - Nature, 2018 - nature.com
Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural
functions 1 , 2 ; however, the precise circuit computations remain unknown. One potentially …

A light-and calcium-gated transcription factor for imaging and manipulating activated neurons

W Wang, CP Wildes, T Pattarabanjird… - Nature …, 2017 - nature.com
Activity remodels neurons, altering their molecular, structural, and electrical characteristics.
To enable the selective characterization and manipulation of these neurons, we present …

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

…, CA Hession, K Miatkowski, CP Wildes… - Protein …, 2010 - Wiley Online Library
Bruton's tyrosine kinase (BTK), a member of the TEC family of kinases, plays a crucial role in
B‐cell maturation and mast cell activation. Although the structures of the unphosphorylated …

[HTML][HTML] Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

…, YT Liu, K Little, JH Jones, NA Powell, CP Wildes… - BMC Structural …, 2016 - Springer
Background The nuclear hormone receptor RORγ regulates transcriptional genes involved
in the production of the pro-inflammatory interleukin IL-17 which has been linked to …

Acute food deprivation rapidly modifies valence-coding microcircuits in the amygdala

…, P Namburi, CA Leppla, CA Siciliano, CP Wildes… - BioRxiv, 2018 - biorxiv.org
In the quest for food, we may expend effort and increase our vulnerability to potential threats.
Motivation to seek food is dynamic, varying with homeostatic need. What mechanisms …