[PDF][PDF] BLA to vHPC inputs modulate anxiety-related behaviors
The basolateral amygdala (BLA) and ventral hippocampus (vHPC) have both been implicated
in mediating anxiety-related behaviors, but the functional contribution of BLA inputs to the …
in mediating anxiety-related behaviors, but the functional contribution of BLA inputs to the …
[PDF][PDF] Divergent routing of positive and negative information from the amygdala during memory retrieval
…, GG Calhoon, GF Conyers, R Luck, CP Wildes… - Neuron, 2016 - cell.com
Although the basolateral amygdala (BLA) is known to play a critical role in the formation of
memories of both positive and negative valence, the coding and routing of valence-related …
memories of both positive and negative valence, the coding and routing of valence-related …
[PDF][PDF] Decoding neural circuits that control compulsive sucrose seeking
…, CA Leppla, R Wichmann, R Neve, CP Wildes… - Cell, 2015 - cell.com
The lateral hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked
to reward processing, but the computations within the LH-VTA loop that give rise to specific …
to reward processing, but the computations within the LH-VTA loop that give rise to specific …
[PDF][PDF] Dorsal raphe dopamine neurons represent the experience of social isolation
…, EM Izadmehr, RE Thomas, GD Lacy, CP Wildes… - Cell, 2016 - cell.com
The motivation to seek social contact may arise from either positive or negative emotional
states, as social interaction can be rewarding and social isolation can be aversive. While …
states, as social interaction can be rewarding and social isolation can be aversive. While …
[PDF][PDF] Organization of valence-encoding and projection-defined neurons in the basolateral amygdala
…, M Silvestre, C Lévêque, P Namburi, CP Wildes… - Cell reports, 2018 - cell.com
The basolateral amygdala (BLA) mediates associative learning for both fear and reward.
Accumulating evidence supports the notion that different BLA projections distinctly alter …
Accumulating evidence supports the notion that different BLA projections distinctly alter …
Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli
Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural
functions 1 , 2 ; however, the precise circuit computations remain unknown. One potentially …
functions 1 , 2 ; however, the precise circuit computations remain unknown. One potentially …
A light-and calcium-gated transcription factor for imaging and manipulating activated neurons
W Wang, CP Wildes, T Pattarabanjird… - Nature …, 2017 - nature.com
Activity remodels neurons, altering their molecular, structural, and electrical characteristics.
To enable the selective characterization and manipulation of these neurons, we present …
To enable the selective characterization and manipulation of these neurons, we present …
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases
…, CA Hession, K Miatkowski, CP Wildes… - Protein …, 2010 - Wiley Online Library
Bruton's tyrosine kinase (BTK), a member of the TEC family of kinases, plays a crucial role in
B‐cell maturation and mast cell activation. Although the structures of the unphosphorylated …
B‐cell maturation and mast cell activation. Although the structures of the unphosphorylated …
[HTML][HTML] Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
…, YT Liu, K Little, JH Jones, NA Powell, CP Wildes… - BMC Structural …, 2016 - Springer
Background The nuclear hormone receptor RORγ regulates transcriptional genes involved
in the production of the pro-inflammatory interleukin IL-17 which has been linked to …
in the production of the pro-inflammatory interleukin IL-17 which has been linked to …
Acute food deprivation rapidly modifies valence-coding microcircuits in the amygdala
In the quest for food, we may expend effort and increase our vulnerability to potential threats.
Motivation to seek food is dynamic, varying with homeostatic need. What mechanisms …
Motivation to seek food is dynamic, varying with homeostatic need. What mechanisms …