The ability of the adaptive immune system to respond to arbitrary pathogens stems from the
broad diversity of immune cell surface receptors (TCRs). This diversity originates in a …

Deletion of Ppm1d, the gene encoding the Wip1 phosphatase, renders cells resistant to
transformation and mice resistant to tumor development. Here, we report that deficiency of Wip1 …

Pancreatic ductal adenocarcinoma (PDAC) is a genomically diverse, prevalent, and almost
invariably fatal malignancy. Although conventional genetically engineered mouse models of …

Germline deletion of the p53 gene in mice gives rise to spontaneous thymic (T-cell) lymphomas.
In this study, the p53 knockout mouse was employed as a model to study the mutational …

The Wip1 phosphatase is an oncogene that is overexpressed in a variety of primary human
cancers. We were interested in identifying genetic variants that could change Wip1 activity. …

Purpose: Tumors activate protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK,
also called EIF2AK3) in response to hypoxia and nutrient deprivation as a stress-mitigation …

The biology of metastatic pancreatic ductal adenocarcinoma (PDAC) is distinct from that of
the primary tumor due to changes in cell plasticity governed by a distinct transcriptome. …

Aberrant Ras/Raf/MEK/ERK signaling is one of the most prevalent oncogenic alterations and
confers survival advantage to tumor cells. Inhibition of this pathway can effectively suppress …

Most targeted anticancer drugs are inhibitors of kinases that are aberrantly activated in cancer
cells. However, the mechanisms by which kinase inhibitors suppress tumor growth remain …

Latent recurrences following curative-intent pancreatic cancer surgery is a major clinical
problem thought to be due to the reactivation of dormant tumor cells that disseminate before the …