User profiles for Cristian Boboila
 | Cristian BoboilaPost-doctoral fellow, Columbia University Verified email at columbia.edu Cited by 2742 |
IgH class switching and translocations use a robust non-classical end-joining pathway
CT Yan, C Boboila, EK Souza, S Franco, TR Hickernell… - Nature, 2007 - nature.com
Immunoglobulin variable region exons are assembled in developing B cells by V(D)J
recombination. Once mature, these cells undergo class-switch recombination (CSR) when …
recombination. Once mature, these cells undergo class-switch recombination (CSR) when …
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks
Classical nonhomologous end joining (C-NHEJ) is one of the two major known pathways for
the repair of DNA double-strand breaks (DSBs) in mammalian cells. Our understanding of C…
the repair of DNA double-strand breaks (DSBs) in mammalian cells. Our understanding of C…
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks
Classical non-homologous DNA end-joining (NHEJ) is a major mammalian DNA double-strand-break
(DSB) repair pathway. Deficiencies for classical NHEJ factors, such as XRCC4, …
(DSB) repair pathway. Deficiencies for classical NHEJ factors, such as XRCC4, …
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70
C Boboila, M Jankovic, CT Yan… - Proceedings of the …, 2010 - National Acad Sciences
Class switch recombination (CSR) in B lymphocytes is initiated by introduction of multiple
DNA double-strand breaks (DSBs) into switch (S) regions that flank immunoglobulin heavy …
DNA double-strand breaks (DSBs) into switch (S) regions that flank immunoglobulin heavy …
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
The classical nonhomologous end-joining (C-NHEJ) DNA double-strand break (DSB) repair
pathway employs the Ku70/80 complex (Ku) for DSB recognition and the XRCC4/DNA …
pathway employs the Ku70/80 complex (Ku) for DSB recognition and the XRCC4/DNA …
Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)
C Boboila, V Oksenych, M Gostissa… - Proceedings of the …, 2012 - National Acad Sciences
Classical nonhomologous DNA end-joining (C-NHEJ), which is a major DNA double-strand
break (DSB) repair pathway in mammalian cells, plays a dominant role in joining DSBs …
break (DSB) repair pathway in mammalian cells, plays a dominant role in joining DSBs …
B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase
…, H Liu, S Diaz, K Haider, C Boboila… - Journal of Experimental …, 2009 - rupress.org
We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate
controls B cell development, signaling, and immunological tolerance. Mice with a mutation in …
controls B cell development, signaling, and immunological tolerance. Mice with a mutation in …
The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers
…, DG Hildebrand, MS Becker, C Boboila… - Advances in …, 2010 - Elsevier
Recurrent chromosomal abnormalities, especially chromosomal translocations, are strongly
associated with certain subtypes of leukemia, lymphoma and solid tumors. The appearance …
associated with certain subtypes of leukemia, lymphoma and solid tumors. The appearance …
Mre11: roles in DNA repair beyond homologous recombination
… Cristian Boboila … Shan Zha, Cristian Boboila, Frederick W. Alt are at the Howard
Hughes Medical Institute, The Children's Hospital, The CBR institute of Biomedical …
Hughes Medical Institute, The Children's Hospital, The CBR institute of Biomedical …
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination
…, MM Murphy, G Li, T Borjeson, C Boboila… - The Journal of …, 2008 - rupress.org
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Artemis are classical
nonhomologous DNA end-joining (C-NHEJ) factors required for joining a subset of DNA …
nonhomologous DNA end-joining (C-NHEJ) factors required for joining a subset of DNA …