The pericardial fluid (PF) is contained in the pericardial sac surrounding the heart.
MicroRNA (miRNA) exchange via exosomes (endogenous nanoparticles) contributes to cell-to-cell …

Introduction Exosome nanoparticles carry a composite cargo, including microRNAs (miRs).
Cultured cardiovascular cells release miR-containing exosomes. The exosomal trafficking of …

Studies on miRNA profiling revealed that a large number of them are significantly deregulated
in human cancers. The molecular mechanisms of this deregulation are not totally clarified, …

Diabetes mellitus is the most common metabolic disorder and is recognised as a dominant
health threat of our time. Diabetes induces a widespread damage of the macro- and …

Effective diabetic kidney disease (DKD) biomarkers remain elusive, and urinary miRNAs
represent a potential source of novel noninvasive disease sentinels. We profiled 754 miRNAs …

Revascularisation is a key step for tissue regeneration and complete organ engineering.
We describe the generation of human platelet lysate gel (hPLG), an extracellular matrix …

Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that
causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro-…

Aristolochic acid nephropathy is characterized by rapidly progressive tubulointerstitial
nephritis culminating in end-stage renal failure and urothelial malignancy. Profibrotic effects of …

Neuroblastoma (NB) is an aggressive infancy tumor, leading cause of death among preschool
age diseases. Here we focused on characterization of exosomal DNA (exo-DNA) isolated …

A pressing need for new chronic kidney disease (CKD) biomarkers persists. MicroRNAs (miRNAs)
are emerging as a novel class of disease biomarkers in body fluids, but mechanisms …