Autophagosomes are unique organelles that form de novo as double-membrane vesicles
engulfing cytosolic material for destruction. Their biogenesis involves membrane …

Cryo-electron tomography (cryo-ET) has the potential to revolutionize our understanding of
the building blocks of life since it provides the unique opportunity to study molecules and …

Synaptic vesicle tethering, priming, and neurotransmitter release require a coordinated
action of multiple protein complexes. While physiological experiments, interaction data, and …

During macroautophagy, phagophores establish multiple membrane contact sites (MCSs)
with other organelles that are pivotal for proper phagophore assembly and growth. In S. …

The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate
many cellular functions, ranging from protein and lipid synthesis to calcium ion flux and inter-…

Highlights • CIK-mediated cytotoxicity of CD56+ target cells is blocked by anti-CD56 mAb •
CD56 knockdown in CIK cells results in reduced cytotoxicity against CD56+ cells • CD56 …

Multiple complexes and biochemical pathways are involved in priming synaptic vesicles
and subsequent neurotransmitter release. While atomic models of reconstituted complexes, …

Cryo-electron tomography (cryo-ET) has become the method of choice for investigating
cellular ultrastructure and molecular complexes in their native, frozen-hydrated state. However, …

Neurotrypsin (NT) is a highly specific nervous system multi-domain serine protease best known
for its selective processing of the potent synaptic organizer agrin. Its enzymatic activity is …

Cryo-electron tomography (Cryo-ET) is currently the principal method for high resolution
visualization of subcellular structures and macromolecular complexes in their native …