Significant advances have been made in the understanding of disease progression in cystic
fibrosis (CF), revealing a complex interplay between host and pathogenic organisms. The …

Pseudomonas aeruginosa is an opportunistic pathogen and causes a wide range of acute
and chronic infections. P. aeruginosa infections are kept in check by an effective immune …

The interleukin (IL)-17A/IL-17 receptor A (IL-17RA) axis is emerging as a key player in host
defence. Several studies have demonstrated that IL-17A-mediated responses play a critical …

Cystic fibrosis (CF) airways disease represents an example of polymicrobial infection
whereby different bacterial species can interact and influence each other. In CF patients …

Pseudomonas aeruginosa can establish life-long airways chronic infection in patients with
cystic fibrosis (CF) with pathogenic variants distinguished from initially acquired strain. Here, …

Background Chronic airway inflammation is the main driver of pathogenesis in respiratory
diseases such as severe asthma, chronic obstructive pulmonary disease, cystic fibrosis (CF) …

We aimed at identifying molecular mechanisms for anti-inflammatory effects of azithromycin (AZM)
suggested by clinical evidences. IL-8 expression and DNA binding activity of two key …

The opportunistic pathogen Pseudomonas aeruginosa is able to thrive in diverse ecological
niches and to cause serious human infection. P. aeruginosa environmental strains are …

Azithromycin (AZM) ameliorates lung function in cystic fibrosis (CF) patients. This macrolide
has been suggested to have anti-inflammatory properties as well as other effects potentially …

Repeated cycles of infections, caused mainly by Pseudomonas aeruginosa, combined with
a robust host immune response and tissue injury, determine the course and outcome of …