Shugoshin-2 (SGOL2) is one of the two mammalian orthologs of the Shugoshin/Mei-S322
family of proteins that regulate sister chromatid cohesion by protecting the integrity of the …

The cohesin complex is a ring‐shaped proteinaceous structure that entraps the two sister
chromatids after replication until the onset of anaphase when the ring is opened by proteolytic …

Cohesin is a conserved multisubunit protein complex that participates in chromosome
segregation, DNA damage repair, chromatin regulation, and synaptonemal complex (SC) …

Sister chromatids are held together by a protein complex named cohesin. Shugoshin
proteins protect cohesin from cleavage by separase during meiosis I in eukaryotes and from …

Meiosis is a fundamental process that generates new combinations between maternal and
paternal genomes and haploid gametes from diploid progenitors. Many of the meiosis-…

Aurora‐A regulates the recruitment of TACC 3 to the mitotic spindle through a phospho‐dependent
interaction with clathrin heavy chain ( CHC ). Here, we describe the structural basis of …

The interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule
polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily …

Skeletal muscle is the largest tissue in mammalian organisms and is a key determinant of
basal metabolic rate and whole‐body energy metabolism. Histone deacetylase 11 (HDAC11) …

10.7554/eLife.07635.001 Kinetochore fibers (K-fibers) of the mitotic spindle are force-generating
units that power chromosome movement during mitosis. K-fibers are composed of many …

Separase halves eukaryotic chromosomes in M‐phase by cleaving cohesin complexes
holding sister chromatids together. Whether this essential protease functions also in interphase …