User profiles for Cristina Leal Rodríguez

Cristina Leal Rodríguez

ZS Associates
Verified email at zs.com
Cited by 218

[HTML][HTML] Expanding known viral diversity in the healthy infant gut

…, MA Rasmussen, TA Redgwell, C Leal Rodríguez… - Nature …, 2023 - nature.com
The gut microbiome is shaped through infancy and impacts the maturation of the immune
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …

[HTML][HTML] Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

…, G Mazzoni, L Niu, JH Biel, C Leal Rodríguez… - Nature …, 2023 - nature.com
The application of multiple omics technologies in biomedical cohorts has the potential to reveal
patient-level disease characteristics and individualized response to treatment. However, …

[HTML][HTML] Application and perspectives of MALDI–TOF mass spectrometry in clinical microbiology laboratories

E Torres-Sangiao, C Leal Rodriguez, C García-Riestra - Microorganisms, 2021 - mdpi.com
Early diagnosis of severe infections requires of a rapid and reliable diagnosis to initiate
appropriate treatment, while avoiding unnecessary antimicrobial use and reducing associated …

The infant gut virome is associated with preschool asthma risk independently of bacteria

C Leal Rodríguez, SA Shah, MA Rasmussen… - Nature Medicine, 2024 - nature.com
Bacteriophage (also known as phage) communities that inhabit the gut have a major effect
on the structure and functioning of bacterial populations, but their roles and association with …

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease

…, OB Pedersen, HG Peleikis, K Peuker, CL Rodriguez… - Gut, 2021 - gut.bmj.com
Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the
population but its aetiology, including suspected genetic predisposition, is poorly understood. …

Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes

C Leal Rodriguez, BS Kaas‐Hansen… - … and Drug Safety, 2022 - Wiley Online Library
… under the supervision of Cristina Leal Rodríguez. Cristina Leal Rodríguez pre-processed
the … Cristina Leal Rodríguez and Benjamin Skov Kaas-Hansen performed the computational …

Language‐agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records

…, D Placido, CL Rodríguez… - Basic & clinical …, 2022 - Wiley Online Library
We sought to craft a drug safety signalling pipeline associating latent information in clinical
free text with exposures to single drugs and drug pairs. Data arose from 12 secondary and …

Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

…, AD Haue, PB Jensen, L Juhl Jensen, CL Rodríguez… - Elife, 2019 - elifesciences.org
Diabetes is a diverse and complex disease, with considerable variation in phenotypic
manifestation and severity. This variation hampers the study of etiological differences and reduces …

[HTML][HTML] Drug dosage modifications in 24 million in-patient prescriptions covering eight years: A Danish population-wide study of polypharmacy

C Leal Rodríguez, AD Haue, G Mazzoni… - PLOS digital …, 2023 - journals.plos.org
Polypharmacy has generally been assessed by raw counts of different drugs administered
concomitantly to the same patients; not with respect to the likelihood of dosage-adjustments. …

Using machine learning to identify patients at high risk of inappropriate drug dosing in periods with renal dysfunction

BS Kaas-Hansen, C Leal Rodríguez… - Clinical …, 2022 - Taylor & Francis
Purpose Dosing of renally cleared drugs in patients with kidney failure often deviates from
clinical guidelines, so we sought to elicit predictors of receiving inappropriate doses of renal …