Persistent inflammation alters the function of the endogenous brain stem cell compartment

…, M Deleidi, C Alfaro-Cervello, G Salani, C Porcheri… - Brain, 2008 - academic.oup.com
Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for
promoting tissue homeostasis and repair after injury, therefore regenerative strategies that …

[HTML][HTML] Physiology, pathology and regeneration of salivary glands

C Porcheri, TA Mitsiadis - Cells, 2019 - mdpi.com
Salivary glands are essential structures in the oral cavity. A variety of diseases, such as
cancer, autoimmune diseases, infections and physical traumas, can alter the functionality of …

Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage

HBF Pohl, C Porcheri, T Mueggler… - Journal of …, 2011 - Soc Neuroscience
Loss of oligodendrocytes is a feature of many demyelinating diseases including multiple
sclerosis. Here, we have established and characterized a novel model of genetically induced …

[HTML][HTML] Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression

CT Meisel, C Porcheri, TA Mitsiadis - Cells, 2020 - mdpi.com
The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate
decisions in both embryonic and adult life. Several aspects of stem cell maintenance are …

[HTML][HTML] Multifactorial contribution of notch signaling in head and neck squamous cell carcinoma

C Porcheri, CT Meisel, T Mitsiadis - International journal of molecular …, 2019 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) defines a group of solid tumors originating
from the mucosa of the upper aerodigestive tract, pharynx, larynx, mouth, and nasal cavity…

Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

C Porcheri, O Golan, FJ Calero‐Nieto… - The EMBO …, 2020 - embopress.org
Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in cluster
structures that protrude into the embryonic aortic lumen. Although much is known about the …

Notch and stem cells

A Bigas, C Porcheri - Molecular Mechanisms of Notch Signaling, 2018 - Springer
The Notch pathway is crucial in the regulation of stem cells biology. Notch-mediated
signalling controls several aspects of tissue homeostasis in both embryonic and adult tissues, …

Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain

C Porcheri, U Suter, S Jessberger - Journal of Neuroscience, 2014 - Soc Neuroscience
Controlling neural stem and progenitor cell (NSPC) proliferation is critical to maintain
neurogenesis in the mammalian brain throughout life. However, it remains poorly understood how …

[HTML][HTML] Molecular and cellular modelling of salivary gland tumors open new landscapes in diagnosis and treatment

C Porcheri, CT Meisel, TA Mitsiadis - Cancers, 2020 - mdpi.com
Simple Summary This review elaborates the current knowledge on salivary gland tumors, with
a specific focus on classical histological classification, cellular mechanisms and molecular …

[HTML][HTML] New scenarios in pharmacological treatments of head and neck squamous cell carcinomas

C Porcheri, TA Mitsiadis - Cancers, 2021 - mdpi.com
Simple Summary Head and neck squamous cell carcinoma (HNSCC) encompasses a variety
of tumors developing in the head and neck region, mainly affecting the oral cavity. The …