Protein phosphorylation is a key post-translational modification regulating protein function
in almost all cellular processes. Although tens of thousands of phosphorylation sites have …

Neuron-microglia co-cultures treated with pro-inflammatory agents are a useful tool to study
neuroinflammation in vitro, where to test the potential neuroprotective effect of anti-…

Living organisms have evolved protein phosphorylation, a rapid and versatile mechanism
that drives signaling and regulates protein function. We report the phosphoproteomes of 18 …

To ensure cell survival and growth during temperature increase, eukaryotic organisms respond
with transcriptional activation that results in accumulation of proteins that protect against …

Phosphorylation is a critical post-translational modification involved in the regulation of
almost all cellular processes. However, fewer than 5% of thousands of recently discovered …

Intracellular bacterial pathogens inject effector proteins to hijack host cellular processes and
promote their survival and proliferation. To systematically map effector-host protein-protein …

Protein phosphorylation is the best characterized post-translational modification that regulates
almost all cellular processes through diverse mechanisms such as changing protein …

Protein kinases lie at the heart of cell-signaling processes and are often mutated in disease.
Kinase target recognition at the active site is in part determined by a few amino acids …

Loss‐of‐function (LoF) mutations associated with disease do not manifest equally in different
individuals. The impact of the genetic background on the consequences of LoF mutations …

Cells have the ability to sense, respond and adapt to environmental fluctuations. Stress causes
a massive reorganization of the transcriptional program. Many examples of histone post-…