Sequence-dependent recognition of dsDNA-binding proteins is well understood, yet
sequence-specific recognition of dsRNA by proteins remains largely unknown, despite their …

PA‐IIL is a fucose‐binding lectin from Pseudomonas aeruginosa that is closely related to
the virulence factors of the bacterium. Previous structural studies have revealed a new …

Recruitment of appropriate RNA processing factors to the site of transcription is controlled
by post-translational modifications of the C-terminal domain (CTD) of RNA polymerase II (…

We analyzed DNA duplexes modified at central guanine residues by monofunctional Ru(II)
arene complexes [(η 6 -arene)Ru(II)(en)(Cl)] + (arene = tetrahydroanthracene or p-cymene, …

More than two decades of genetic research have identified and assigned main biological
functions of shelterin proteins that safeguard telomeres. However, a molecular mechanism of …

Non-coding RNA polymerase II transcripts are processed by the poly(A)-independent
termination pathway that requires the Nrd1 complex. The Nrd1 complex includes two RNA-binding …

Telomeric repeat binding factor 2 (TRF2) folds human telomeres into loops to prevent
unwanted DNA repair and chromosome end-joining. The N-terminal basic domain of TRF2 (B-…

The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by
telomere-associated proteins, which form the shelterin complex in mammals. Recent works …

Telomeres are nucleoprotein structures ensuring the stability of eukaryotic chromosome
ends. Two protein families, TRFL (TFL-Like) and SMH (Single-Myb-Histone), containing a …

Protein phosphatase magnesium-dependent 1 delta (PPM1D) terminates the cell cycle
checkpoint by dephosphorylating the tumour suppressor protein p53. By targeting additional …