User profiles for Curt R. Fischer

Curt Fischer

Octant Bio
Verified email at octant.bio
Cited by 4317

A metabolomics pipeline for the mechanistic interrogation of the gut microbiome

S Han, W Van Treuren, CR Fischer, BD Merrill… - Nature, 2021 - nature.com
Gut microorganisms modulate host phenotypes and are associated with numerous health
effects in humans, ranging from host responses to cancer immunotherapy to metabolic …

Selection and optimization of microbial hosts for biofuels production

CR Fischer, D Klein-Marcuschamer… - Metabolic …, 2008 - Elsevier
Currently, the predominant microbially produced biofuel is starch- or sugar-derived ethanol.
However, ethanol is not an ideal fuel molecule, and lignocellulosic feedstocks are …

Engineering of Promoter Replacement Cassettes for Fine-Tuning of Gene Expression in Saccharomyces cerevisiae

E Nevoigt, J Kohnke, CR Fischer, H Alper… - Applied and …, 2006 - Am Soc Microbiol
The strong overexpression or complete deletion of a gene gives only limited information
about its control over a certain phenotype or pathway. Gene function studies based on these …

N-hydroxy-pipecolic acid is a mobile metabolite that induces systemic disease resistance in Arabidopsis

…, JG Kim, S Tang, CR Fischer… - Proceedings of the …, 2018 - National Acad Sciences
Systemic acquired resistance (SAR) is a global response in plants induced at the site of
infection that leads to long-lasting and broad-spectrum disease resistance at distal, uninfected …

Coevolution of Bacteriophage PP01 and Escherichia coli O157:H7 in Continuous Culture

K Mizoguchi, M Morita, CR Fischer… - Applied and …, 2003 - Am Soc Microbiol
The interaction between Escherichia coli O157:H7 and its specific bacteriophage PP01 was
investigated in chemostat continuous culture. Following the addition of bacteriophage PP01, …

HEx: A heterologous expression platform for the discovery of fungal natural products

…, M Tang, U Schlecht, J Horecka, CR Fischer… - Science …, 2018 - science.org
For decades, fungi have been a source of US Food and Drug Administration–approved natural
products such as penicillin, cyclosporine, and the statins. Recent breakthroughs in DNA …

Depletion of microbiome-derived molecules in the host using Clostridium genetics

…, S Higginbottom, K Nagashima, CR Fischer… - Science, 2019 - science.org
INTRODUCTION The gut microbiota produce hundreds of molecules that are present at
high concentrations in circulation and whose levels vary widely among humans. These …

[PDF][PDF] Genetic mapping and biochemical basis of yellow feather pigmentation in budgerigars

TF Cooke, CR Fischer, P Wu, TX Jiang, KT Xie, J Kuo… - Cell, 2017 - cell.com
Parrot feathers contain red, orange, and yellow polyene pigments called psittacofulvins.
Budgerigars are parrots that have been extensively bred for plumage traits during the last …

[PDF][PDF] A pathogen-responsive gene cluster for highly modified fatty acids in tomato

JE Jeon, JG Kim, CR Fischer, N Mehta… - Cell, 2020 - cell.com
In response to biotic stress, plants produce suites of highly modified fatty acids that bear
unusual chemical functionalities. Despite their chemical complexity and proposed roles in …

[PDF][PDF] A metabolic pathway for activation of dietary glucosinolates by a human gut symbiont

CS Liou, SJ Sirk, CAC Diaz, AP Klein, CR Fischer… - Cell, 2020 - cell.com
Consumption of glucosinolates, pro-drug-like metabolites abundant in Brassica vegetables,
has been associated with decreased risk of certain cancers. Gut microbiota have the ability …