High-throughput screens have begun to reveal the protein interaction network that underpins
most cellular functions in the yeastSaccharomyces cerevisiae. How the organization of this …

Deleting a gene in an organism often has little phenotypic effect 1 , 2 , 3 , 4 , 5 , owing to two
mechanisms of compensation 4 , 5 , 6 , 7 , 8 , 9 , 10 . The first is the existence of duplicate …

Wolfram syndrome is an autosomal recessive disorder characterized by juvenile diabetes
mellitus, diabetes insipidus, optic atrophy and a number of neurological symptoms including …

High mutation rate in mammalian mitochondrial DNA generates a highly divergent pool of
alleles even within species that have dispersed and expanded in size recently. Phylogenetic …

High similarity between yeast and human mitochondria allows functional genomic study of
Saccharomyces cerevisiae to be used to identify human genes involved in disease 1. So far, …

X-linked congenital stationary night blindness (XLCSNB) is characterized by impaired
scotopic vision with associated ocular symptoms such as myopia, hyperopia, nystagmus and …

In this study yeast mitochondria were used as a model system to apply, evaluate, and
integrate different genomic approaches to define the proteins of an organelle. Liquid …

Nuclear genes encode most mitochondrial proteins, and their mutations cause diverse and
debilitating clinical disorders. To date, 1,200 of these mitochondrial genes have been …

Success rates for genomic analyses of highly heterogeneous disorders can be greatly
improved if a large cohort of patient data is assembled to enhance collective capabilities for …

Genetic changes that altered the function of gene regulatory elements have been implicated
in the evolution of human traits such as the expansion of the cerebral cortex. However, …