Background: It is not clear whether careful history taking with detailed questioning of the
characteristics of cough is diagnostically useful. Objective: To determine if the character, timing, …

Human genome variation contributes to diversity in neurodevelopmental outcomes and
vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require …

Meiosis, although essential for reproduction, is also variable and error-prone: rates of
chromosome crossover vary among gametes, between the sexes, and among humans of the same …

Tens of thousands of genetic variants shape human phenotypes, mostly by unknown cellular
mechanisms. Here we describe Census-seq, a way to measure cellular phenotypes in cells …

Human pluripotent stem cells (hPSCs) are a powerful tool for disease modeling of hard-to-access
tissues (such as the brain). Current protocols either direct neuronal differentiation with …

Variation in the human genome contributes to abundant diversity in human traits and
vulnerabilities, but the underlying molecular and cellular mechanisms are not yet known, and will …

Non-invasive prenatal testing (NIPT) to detect fetal aneuploidy by sequencing the cell-free
DNA (cfDNA) in maternal plasma is being broadly adopted. To detect fetal aneuploidies from …

A previously healthy 23-year-old man presented to his primary care physician with a 1-week
history of fever, sore throat, and progressive fatigue and malaise. Physical examination was …

Meiosis, while critical for reproduction, is also highly variable and error prone: crossover
rates vary among humans and individual gametes, and chromosome nondisjunction leads to …

Quantifying SARS-CoV-2 infectivity, formulating well-calibrated public-health policy, and
managing the safety of workplaces would all be facilitated by precise measurement of the extent …