The onset of inflammation is associated with reactive oxygen species and oxidative damage
to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine …

The cytostatic deoxycytidine analog cytarabine (ara-C) is the most active agent available
against acute myelogenous leukemia (AML). Together with anthracyclines, ara-C forms the …

Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs that,
starting from the small field of paediatric oncology, in combination with other …

The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
is consistently overexpressed in cancer but its roles are not fully characterized, and …

Recently, we demonstrated that sterile α motif and HD domain containing protein 1 (SAMHD1)
is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity of …

The deoxycytidine analogue cytarabine (ara‐C) remains the backbone treatment of acute
myeloid leukaemia ( AML ) as well as other haematological and lymphoid malignancies, but …

Highlights • Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 is a
deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase that is involved in cellular …

The antimetabolite 5-Fluorouracil (5-FU) is used in the treatment of various forms of cancer
and has a complex mode of action. Despite 6 decades in clinical application the contribution …

Due to a polar or even charged binding interface, DNA-binding proteins are considered
extraordinarily difficult targets for development of small-molecule ligands and only a handful of …

SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can
detoxify chemotherapy metabolites controlling their clinical responses. To understand …