Recent findings indicate that the inhalation of large manufactured porous particles may be
particularly effective for drug delivery. In this study, a mathematical model was employed to …

Quantitative systems pharmacology models mechanistically describe a biological system
and the effect of drug treatment on system behavior. Because these models rarely are …

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic requires
the rapid development of efficacious treatments for patients with life‐threatening coronavirus …

The most widely used particle dosimetry models are those proposed by the National Council
on Radiation Protection, International Commission for Radiological Protection, and the …

<p>To ascertain the threat to human health posed by the inhalation of the particulate phase
for secondary cigarette smoke (SCS), it is necessary to determine the doses delivered to …

Quantitative systems pharmacology (QSP) models aim to describe mechanistically the
pathophysiology of disease and predict the effects of therapies on that disease. For most drug …

Cardiac contraction is the result of integrated cellular, tissue and organ function. Biophysical
in silico cardiac models offer a systematic approach for studying these multi-scale …

PF-05231023, a long-acting FGF21 analogue, is a promising potential pharmacotherapy for
the treatment of obesity and associated comorbidities. Previous studies have shown the …

The pharmaceutical industry is actively applying quantitative systems pharmacology (QSP)
to make internal decisions and guide drug development. To facilitate the eventual …

A crucial question that must be addressed in the drug development process is whether the
proposed therapeutic target will yield the desired effect in the clinical population. …