Detecting differential growth of microbial populations with Gaussian process regression

PD Tonner, CL Darnell, BE Engelhardt… - Genome …, 2017 - genome.cshlp.org
Microbial growth curves are used to study differential effects of media, genetics, and stress
on microbial population growth. Consequently, many modeling frameworks exist to capture …

RscS Functions Upstream of SypG To Control the syp Locus and Biofilm Formation in Vibrio fischeri

EA Hussa, CL Darnell, KL Visick - Journal of Bacteriology, 2008 - Am Soc Microbiol
Two-component signal transduction systems, composed of sensor kinase (SK) and response
regulator (RR) proteins, allow bacterial cells to adapt to changes such as environmental …

The Putative Hybrid Sensor Kinase SypF Coordinates Biofilm Formation in Vibrio fischeri by Acting Upstream of Two Response Regulators, SypG and VpsR

CL Darnell, EA Hussa, KL Visick - Journal of Bacteriology, 2008 - Am Soc Microbiol
Colonization of the Hawaiian squid Euprymna scolopes by the marine bacterium Vibrio fischeri
requires the symbiosis polysaccharide (syp) gene cluster, which contributes to symbiotic …

Two-Component Response Regulators of Vibrio fischeri: Identification, Mutagenesis, and Characterization

EA Hussa, TM O'Shea, CL Darnell, EG Ruby… - Journal of …, 2007 - Am Soc Microbiol
Two-component signal transduction systems are utilized by prokaryotic and eukaryotic cells
to sense and respond to environmental stimuli, both to maintain homeostasis and to rapidly …

Inactivation of a novel response regulator is necessary for biofilm formation and host colonization by Vibrio fischeri

AR Morris, CL Darnell, KL Visick - Molecular microbiology, 2011 - Wiley Online Library
The marine bacterium Vibrio fischeri uses a biofilm to promote colonization of its eukaryotic
host Euprymna scolopes. This biofilm depends on the symbiosis polysaccharide (syp) locus, …

[HTML][HTML] A conserved transcription factor controls gluconeogenesis via distinct targets in hypersaline-adapted archaea with diverse metabolic capabilities

RK Hackley, A Vreugdenhil-Hayslette, CL Darnell… - Plos …, 2024 - journals.plos.org
Timely regulation of carbon metabolic pathways is essential for cellular processes and to
prevent futile cycling of intracellular metabolites. In Halobacterium salinarum, a hypersaline …

Transcriptional regulation in archaea: from individual genes to global regulatory networks

…, PD Tonner, CL Darnell… - Annual review of …, 2017 - annualreviews.org
Archaea are major contributors to biogeochemical cycles, possess unique metabolic capabilities,
and resist extreme stress. To regulate the expression of genes encoding these unique …

Draft genome sequence of Myxococcus xanthus wild-type strain DZ2, a model organism for predation and development

S Müller, JW Willett, SM Bahr, CL Darnell… - Genome …, 2013 - Am Soc Microbiol
Myxococcus xanthus is a member of the Myxococcales order within the Deltaproteobacteria
subdivision. The myxobacteria reside in soil, have relatively large genomes, and display …

The Ribbon-Helix-Helix Domain Protein CdrS Regulates the Tubulin Homolog ftsZ2 To Control Cell Division in Archaea

CL Darnell, J Zheng, S Wilson, RM Bertoli… - MBio, 2020 - Am Soc Microbiol
Precise control of the cell cycle is central to the physiology of all cells. In prior work we
demonstrated that archaeal cells maintain a constant size; however, the regulatory mechanisms …

Systematic discovery of archaeal transcription factor functions in regulatory networks through quantitative phenotyping analysis

CL Darnell, PD Tonner, JG Gulli, SC Schmidler… - …, 2017 - Am Soc Microbiol
Gene regulatory networks (GRNs) are critical for dynamic transcriptional responses to
environmental stress. However, the mechanisms by which GRN regulation adjusts physiology to …