Members of the Hedgehog (Hh) family of secreted proteins have been identified recently as
key signaling molecules that regulate a variety of inductive interactions central to the …

Wnts are evolutionarily conserved secreted signalling proteins that, in various developmental
contexts, spread from their site of synthesis to form a gradient and activate target-gene …

To facilitate studies of neural network architecture and formation, we generated three
Drosophila melanogaster variants of the mouse Brainbow-2 system, called Flybow. Sequences …

Gene targeting by ‘ends-out’ homologous recombination enables the deletion of genomic
sequences and concurrent introduction of exogenous DNA with base-pair precision without …

Wingless acts as a morphogen in Drosophila wing discs, where it specifies cell fates and
controls growth several cell diameters away from its site of expression. Thus, despite being …

Embryos have evolved various strategies to confine the action of secreted signals. Using an
HRP-Wingless fusion protein to track the fate of endocytosed Wingless, we show that …

Cells with distinct developmental histories can respond differentially to identical signals,
suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might …

The two glypicans Dally and Dally-like have been implicated in modulating the activity of
Wingless, a member of the Wnt family of secreted glycoprotein. So far, the lack of null mutants …

Ribosomes are multicomponent molecular machines that synthesize all of the proteins of
living cells. Most of the genes that encode the protein components of ribosomes are therefore …

The apical and basolateral membranes of epithelia are insulated from each other, preventing
the transfer of extracellular proteins from one side to the other 1 . Thus, a signalling protein …