The capacity to diversify genetic codes advances our ability to understand and engineer
biological systems 1 , 2 . A method for continuously diversifying user-defined regions of a …

Betalains are a family of natural pigments found exclusively in the plant order Caryophyllales.
All members of this chemical family are biosynthesized through the common intermediate …

Droplet-based microfluidic systems generate, manipulate and control sub-microlitre droplets
enclosed within an immiscible carrier fluid. Owing to a number of remarkable features, such …

Enzymes are represented across a vast space of protein sequences and structural forms
and have activities that far exceed the best chemical catalysts; however, engineering them to …

Self-associating split fluorescent proteins (FPs) are split FPs whose two fragments spontaneously
associate to form a functional FP. They have been widely used for labeling proteins, …

Droplet-based bioprinting has long struggled with the manipulation and dispensation of
individual cells from a printhead, hindering the fabrication of artificial cellular structures with high …

Targeting specific cells for sequencing is important for applications in cancer, microbiology,
and infectious disease. Nucleic acid cytometry (NAC) is a powerful approach for …

Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry
by segregating and concentrating analytes, but their fabrication can be challenging. …

Single cell sequencing is useful for resolving complex systems into their composite cell types
and computationally mining them for unique features that are masked in pooled sequencing…

Microbial biosynthetic gene clusters are a valuable source of bioactive molecules. However,
because they typically represent a small fraction of genomic material in most metagenomic …