It has recently emerged that endothelial dysfunction is an early step in the development of
atherosclerosis and is mainly characterised by a reduction in the bioavailability of nitric oxide. …

… and D′ values equal to 1. If a perfectly tagging SNP was not available, we selected a SNP
that had equivalent MAF and the highest possible r 2 and D′ values. Estimation of r 2 and D…

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most
common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

There is evidence across several species for genetic control of phenotypic variation of
complex traits 1 , 2 , 3 , 4 , such that the variance among phenotypes is genotype dependent. …

Background Abnormalities in renal sodium transport may be involved in hypertension. Adducin,
an α/β heterodimeric protein found in the renal tubule is thought to regulate ion transport …

Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …

Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness
with complex genetic etiology. The International OCD Foundation Genetics Collaborative (…

IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney-biopsy-…

… by ethnicity, (panel b) the prevalence of ESRD due to IgAN per million population by
ethnicity, (panel c) percent of IgAN among the total ESRD population by ethnicity; and (panel d) …