Polymeric substrates are being identified that could permit translation of human pluripotent
stem cells from laboratory-based research to industrial-scale biomedicine. Well-defined …

Current data indicate that there is a significant risk of endometrial cancer (EC) in women with
polycystic ovarian syndrome (PCOS), although further research needed to clarify the exact …

The mechanisms leading to neuronal death in neurodegenerative disease are poorly
understood. Many of these disorders, including Alzheimer’s, Parkinson’s and prion diseases, are …

During prion disease, an increase in misfolded prion protein (PrP) generated by prion
replication leads to sustained overactivation of the branch of the unfolded protein response (UPR) …

Introduction Cannabis-based medicines have a number of therapeutic indications, including
anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including …

Background and purpose: The endocannabinoid N‐arachidonoylethanolamide (anandamide)
is co‐synthesized with other N‐acylethanolamides, namely N‐palmitoylethanolamide (…

Although omeprazole is an important component in anti-Helicobacter pylori therapeutic
regimes using clarithromycin, amoxycillin and metronidazole, the mechanism by which it …

Activation of the PERK branch of the unfolded protein response (UPR) in response to protein
misfolding within the endoplasmic reticulum (ER) results in the transient repression of …

Background: Broccoli consumption is associated with a reduction in the risk of cancer,
particularly in persons with a functional glutathione S-transferase M1 allele, as opposed rotrose …

A novel plasma-assisted desorption/ionization (PADI) method that can be coupled with
atmospheric pressure sampling mass spectrometry to yield mass spectral information under …