User profiles for D. A. Joy
David JoyVerified email at dnli.com Cited by 778 |
[HTML][HTML] Host-malaria parasite interactions and impacts on mutual evolution
X Su, C Zhang, DA Joy - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Malaria is the most deadly parasitic disease, affecting hundreds of millions of people worldwide.
Malaria parasites have been associated with their hosts for millions of years. During the …
Malaria parasites have been associated with their hosts for millions of years. During the …
Early Origin and Recent Expansion of Plasmodium falciparum
DA Joy, X Feng, J Mu, T Furuya, K Chotivanich… - science, 2003 - science.org
The emergence of virulent Plasmodium falciparumin Africa within the past 6000 years as a
result of a cascade of changes in human behavior and mosquito transmission has recently …
result of a cascade of changes in human behavior and mosquito transmission has recently …
Multiple transporters associated with malaria parasite responses to chloroquine and quinine
J Mu, MT Ferdig, X Feng, DA Joy, J Duan… - Molecular …, 2003 - Wiley Online Library
Mutations and/or overexpression of various transporters are known to confer drug resistance
in a variety of organisms. In the malaria parasite Plasmodium falciparum, a homologue of P‐…
in a variety of organisms. In the malaria parasite Plasmodium falciparum, a homologue of P‐…
Dissecting the loci of low‐level quinine resistance in malaria parasites
…, RA Cooper, J Mu, B Deng, DA Joy… - Molecular …, 2004 - Wiley Online Library
Quinine (QN) remains effective against Plasmodium falciparum, but its decreasing efficacy is
documented from different continents. Multiple genes are likely to contribute to the evolution …
documented from different continents. Multiple genes are likely to contribute to the evolution …
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of
patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell …
patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell …
Host Switch Leads to Emergence of Plasmodium vivax Malaria in Humans
J Mu, DA Joy, J Duan, Y Huang… - Molecular biology …, 2005 - academic.oup.com
The geographical origin of Plasmodium vivax, the most widespread human malaria parasite,
is controversial. Although genetic closeness to Asian primate malarias has been confirmed …
is controversial. Although genetic closeness to Asian primate malarias has been confirmed …
[HTML][HTML] Recombination Hotspots and Population Structure in Plasmodium falciparum
J Mu, P Awadalla, J Duan, KM McGee, DA Joy… - PLoS …, 2005 - journals.plos.org
Understanding the influences of population structure, selection, and recombination on
polymorphism and linkage disequilibrium (LD) is integral to mapping genes contributing to drug …
polymorphism and linkage disequilibrium (LD) is integral to mapping genes contributing to drug …
[PDF][PDF] Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids
AC Silva, OB Matthys, DA Joy, MA Kauss, V Natarajan… - Cell stem cell, 2021 - cell.com
During embryogenesis, paracrine signaling between tissues in close proximity contributes
to the determination of their respective cell fate(s) and development into functional organs. …
to the determination of their respective cell fate(s) and development into functional organs. …
Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum
The Malaria's Eve hypothesis, proposing a severe recent population bottleneck (about 3,000–5,000
years ago) of the human malaria parasite Plasmodium falciparum, has prompted a …
years ago) of the human malaria parasite Plasmodium falciparum, has prompted a …
Axial elongation of caudalized human organoids mimics aspects of neural tube development
Axial elongation of the neural tube is crucial during mammalian embryogenesis for anterior-posterior
body axis establishment and subsequent spinal cord development, but these …
body axis establishment and subsequent spinal cord development, but these …