Characterization of the cardiac cellulome, the network of cells that form the heart, is essential
for understanding cardiac development and normal organ function and for formulating …

Saccharomyces cerevisiae, a well-established model for species as diverse as humans and
pathogenic fungi, is more recently a model for population and quantitative genetics. S. …

Variation in gene expression is thought to make a significant contribution to phenotypic
diversity among individuals within populations. Although high-throughput cDNA sequencing …

Variation in gene expression constitutes an important source of biological variability within
and between populations that is likely to contribute significantly to phenotypic diversity. …

Background: Cardiac fibrosis is a key antecedent to many types of cardiac dysfunction including
heart failure. Physiological factors leading to cardiac fibrosis have been recognized for …

Cardiac ischemia leads to the loss of myocardial tissue and the activation of a repair process
that culminates in the formation of a scar whose structural characteristics dictate propensity …

To better understand the quantitative characteristics and structure of phenotypic diversity,
we measured over 14,000 transcript, protein, metabolite, and morphological traits in 22 …

Little is known about the molecular changes that take place in the kidney during the aging
process. In order to better understand these changes, we measured mRNA and protein levels …

Genetic and genome-wide association studies suggest a central role for microglia in Alzheimer's
disease (AD). However, single-cell RNA sequencing (scRNA-seq) of microglia in mice, …

Background: Ischemic heart disease is a leading cause of heart failure and despite
advanced therapeutic options, morbidity and mortality rates remain high. Although acute …