[HTML][HTML] MetaBAT 2: an adaptive binning algorithm for robust and efficient genome reconstruction from metagenome assemblies
We previously reported on MetaBAT, an automated metagenome binning software tool to
reconstruct single genomes from microbial communities for subsequent analyses of …
reconstruct single genomes from microbial communities for subsequent analyses of …
[HTML][HTML] MetaBAT, an efficient tool for accurately reconstructing single genomes from complex microbial communities
Grouping large genomic fragments assembled from shotgun metagenomic sequences to
deconvolute complex microbial communities, or metagenome binning, enables the study of …
deconvolute complex microbial communities, or metagenome binning, enables the study of …
Delivery of CRISPR-Cas9 system for screening and editing RNA binding proteins in cancer
RNA-binding proteins (RBPs) play an important role in RNA metabolism, regulating the stability,
localization, and functional dynamics of RNAs. Alternation in the RBP-RNA network has …
localization, and functional dynamics of RNAs. Alternation in the RBP-RNA network has …
[HTML][HTML] The epigenomic landscape of prokaryotes
…, A Fomenkov, R Fries, J Froula, DD Kang… - PLoS …, 2016 - journals.plos.org
DNA methylation acts in concert with restriction enzymes to protect the integrity of prokaryotic
genomes. Studies in a limited number of organisms suggest that methylation also …
genomes. Studies in a limited number of organisms suggest that methylation also …
Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy
Cytokines are important immunotherapeutics with approved drugs for the treatment of human
cancers. However, systemic administration of cytokines often fails to achieve adequate …
cancers. However, systemic administration of cytokines often fails to achieve adequate …
Harnessing lipid nanoparticles for efficient CRISPR delivery
The CRISPR-Cas system has revolutionized the biomedical research field with its simple and
flexible genome editing method. In October 2020, Emmanuelle Charpentier and Jennifer A…
flexible genome editing method. In October 2020, Emmanuelle Charpentier and Jennifer A…
An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection
With the rapid advances and prevalence of high-throughput genomic technologies, integrating
information of multiple relevant genomic studies has brought new challenges. Microarray …
information of multiple relevant genomic studies has brought new challenges. Microarray …
[HTML][HTML] Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy
Antibodies targeting costimulatory receptors of T cells have been developed for the activation
of T cell immunity in cancer immunotherapy. However, costimulatory molecule expression …
of T cell immunity in cancer immunotherapy. However, costimulatory molecule expression …
STING agonist-derived LNP-mRNA vaccine enhances protective immunity against SARS-CoV-2
Lipid nanoparticle (LNP)-mediated delivery of messenger RNA (mRNA) COVID-19 vaccines
has provided large-scale immune protection to the public. To elicit a robust immune …
has provided large-scale immune protection to the public. To elicit a robust immune …
[HTML][HTML] Profiling early lung immune responses in the mouse model of tuberculosis
Tuberculosis (TB) is caused by the intracellular bacteria Mycobacterium tuberculosis, and
kills more than 1.5 million people every year worldwide. Immunity to TB is associated with the …
kills more than 1.5 million people every year worldwide. Immunity to TB is associated with the …