User profiles for D. G. Anderson
 | Daniel G. AndersonMassachusetts Institute of Technology Verified email at mit.edu Cited by 88233 |
[HTML][HTML] Knocking down barriers: advances in siRNA delivery
In the 10 years that have passed since the Nobel prize-winning discovery of RNA interference
(RNAi), billions of dollars have been invested in the therapeutic application of gene …
(RNAi), billions of dollars have been invested in the therapeutic application of gene …
Non-viral vectors for gene-based therapy
… Finally, the MD Anderson Cancer Center has initiated a clinical trial for their formulation of
siRNA–EphA2–DOPC, in which siRNA is incorporated into neutral liposomes composed of …
siRNA–EphA2–DOPC, in which siRNA is incorporated into neutral liposomes composed of …
Physical and mechanical properties of PLA, and their functions in widespread applications—A comprehensive review
Poly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable
aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for …
aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for …
[HTML][HTML] CRISPR-Cas9 knockin mice for genome editing and cancer modeling
…, M Heidenreich, RJ Xavier, R Langer, DG Anderson… - Cell, 2014 - cell.com
CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic
elements. To broadly enable the application of Cas9 in vivo, we established a Cre-…
elements. To broadly enable the application of Cas9 in vivo, we established a Cre-…
[HTML][HTML] The clinical progress of mRNA vaccines and immunotherapies
The emergency use authorizations (EUAs) of two mRNA-based severe acute respiratory
syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after publication of the …
syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after publication of the …
A new classification of thoracolumbar injuries: the importance of injury morphology, the integrity of the posterior ligamentous complex, and neurologic status
…, MG Fehlings, C Fisher, SC Zeiller, DG Anderson… - Spine, 2005 - journals.lww.com
Study Design. A new proposed classification system for thoracolumbar (TL) spine injuries,
including injury severity assessment, designed to assist in clinical management. Objective. To …
including injury severity assessment, designed to assist in clinical management. Objective. To …
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
…, TS Zimmermann, R Langer, DG Anderson - Nature …, 2008 - nature.com
The safe and effective delivery of RNA interference (RNAi) therapeutics remains an important
challenge for clinical development. The diversity of current delivery materials remains …
challenge for clinical development. The diversity of current delivery materials remains …
CRISPR-mediated direct mutation of cancer genes in the mouse liver
…, R Bronson, DG Crowley, F Zhang, DG Anderson… - Nature, 2014 - nature.com
The study of cancer genes in mouse models has traditionally relied on genetically-engineered
strains made via transgenesis or gene targeting in embryonic stem cells 1 . Here we …
strains made via transgenesis or gene targeting in embryonic stem cells 1 . Here we …
Simple and rapid method for isolating large plasmid DNA from lactic streptococci
DG Anderson, LL Mckay - Applied and environmental …, 1983 - Am Soc Microbiol
A procedure for the rapid isolation of plasmid DNA larger than 30 megadaltons from lactic
streptococci is described. This protocol can be used on a preparative scale to isolate sufficient …
streptococci is described. This protocol can be used on a preparative scale to isolate sufficient …
Treating metastatic cancer with nanotechnology
Metastasis accounts for the vast majority of cancer deaths. The unique challenges for
treating metastases include their small size, high multiplicity and dispersion to diverse organ …
treating metastases include their small size, high multiplicity and dispersion to diverse organ …