Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …

Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …

We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the
association between the disorder and chromosomal copy number (CNV) burden. We combined …

Causal genes and variants within genome-wide association study (GWAS) loci can be
identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and …

Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific
roles underlying disease liability remain poorly characterized. We have generated for two …

After two decades of frustration, genetic studies of schizophrenia have entered an era of
spectacular success. Advances in genotyping technologies and high throughput sequencing, …

Background Common genetic variants in and around the gene encoding transcription factor
4 (TCF4) are associated with an increased risk of schizophrenia. Conversely, rare damaging …

Schizophrenia is a highly heritable disorder. Genome-wide association studies based largely
on common alleles have identified over 100 schizophrenia risk loci, but it is also evident …

… Kavanagh a b , Aslihan Dincer a b , Leanne Brown a , Venu Pothula a , Elizabeth Zharovsky
a , Royce Park a , Rivka Jacobov a , Isabelle Magro a , Bibi Kassim a , Jennifer Wiseman a , …