Reports the efforts of six British small and medium enterprises (SMEs) to enhance their new
product development (NPD) capabilities. Finds a strong recognition by managers of “the …

Defining the transition from benign to malignant tissue is fundamental to improving early
diagnosis of cancer 1 . Here we use a systematic approach to study spatial genome integrity in …

In individual mammalian cells the expression of some genes such as prolactin is highly
variable over time and has been suggested to occur in stochastic pulses. To investigate the …

Prostate cancer represents a substantial clinical challenge because it is difficult to predict
outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 …

Context Studies characterising genomic changes in prostate cancer (PCa) during natural
progression have greatly increased our understanding of the disease. A better understanding …

Nuclear factor kappa B (NF-κB) signalling is activated by cellular stress and inflammation
and regulates cytokine expression. We applied single-cell imaging to investigate dynamic …

The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas
(malignant) remain largely undetermined. Using multi-region genome and exome …

Recent studies show that aneuploidy and driver gene mutations precede cancer diagnosis
by many years 1 , 2 , 3 – 4 . We assess whether these genomic signals can be used for early …

Reports the product innovation activities of 30 British manufacturing SMEs, all with aggressive
growth ambitions. Shows that ten of these companies meet their aims by repeatedly …

The evolutionary progression from primary to metastatic prostate cancer is largely uncharted,
and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of …