Background - As circulating tumour DNA (ctDNA) liquid biopsy analysis is increasingly
incorporated into modern oncological practice, establishing the impact of genomic intra-tumoural …

The common analgesic paracetamol enhances the anti-tumour activity of decitabine through
exacerbation of oxidative stress Conf Page 1 1 The common analgesic paracetamol enhances …

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying …

Background Medulloblastoma (MB) is a highly malignant and heterogeneous brain tumour
that is the most common cause of cancer-related deaths in children. Increasing availability of …

The DNA demethylating agent 5-aza-2′-deoxycytidine (DAC, decitabine) has anti-cancer
therapeutic potential, but its clinical efficacy is hindered by DNA damage-related side effects …

… Deena MA Gendoo is a postdoctoral research fellow at the Princess Margaret Cancer Centre,
Canada. Her research focuses on translational bioinformatics in multiple cancer types, as …

Detection of amyloidogenic peptides or domains in proteins is of paramount importance towards
understanding their role in amyloidosis in conformational diseases. This thesis explores …

Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor
suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor …

Background Triple-negative breast cancer (TNBC) represents a heterogeneous group of ER-
and HER2-negative tumors with poor clinical outcome. We recently reported that Pten-loss …

Background Systemic inflammation is involved in the development of acute kidney injury (AKI)
after cardiac surgery with cardiopulmonary bypass (CPB). Ulinastatin, a urinary trypsin …