Human apolipoprotein E (apoE) is a member of the family of soluble apolipoproteins. Through
its interaction with members of the low-density lipoprotein receptor family, apoE has a key …

A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS)…

Huntington's disease is one of the several neurodegenerative diseases caused by dominant
mutations that expand the number of glutamine codons within an existing poly‐glutamine (…

Human apolipoprotein C-II (apoC-II) slowly forms amyloid fibers in lipid-free solutions at
physiological pH and salt concentrations (Hatters, DM, MacPhee, CE, Lawrence, LJ, Sawyer, WH…

The amino-terminal domain of apolipoprotein (apo) E4 is less susceptible to chemical and
thermal denaturation than the apoE3 and apoE2 domains. We compared the urea …

Amyotrophic lateral sclerosis is a rapidly progressing neurodegenerative disease associated
with protein misfolding and aggregation. Most cases are characterized by TDP-43 positive …

The self-association of proteins to form amyloid fibrils has been implicated in the
pathogenesis of a number of diseases including Alzheimer's, Parkinson's, and Creutzfeldt-Jakob …

When proteostasis becomes unbalanced, unfolded proteins can accumulate and aggregate.
Here we report that the dye, tetraphenylethene maleimide (TPE-MI) can be used to …

Huntington disease is caused by expanded polyglutamine sequences in huntingtin, which
procures its aggregation into intracellular inclusion bodies (IBs). Aggregate intermediates, …

Aberrant phase separation of globular proteins is associated with many diseases. Here, we
use a model protein system to understand how the unfolded states of globular proteins drive …