The fly Drosophila melanogaster is one of the most intensively studied organisms in biology
and serves as a model system for the investigation of many developmental and cellular …

Determining the genetic basis of cancer requires comprehensive analyses of large collections
of histopathologically well-classified primary tumours. Here we report the results of a …

The association of genetic variation with disease and drug response, and improvements in
nucleic acid technologies, have given great optimism for the impact of ‘genomic medicine’. …

Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …

Background Whole-exome sequencing is a diagnostic approach for the identification of
molecular defects in patients with suspected genetic disorders. Methods We developed technical…

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and …

A major challenge of biology is understanding the relationship between molecular genetic
variation and variation in quantitative traits, including fitness. This relationship determines our …

To understand the biology and evolution of ruminants, the cattle genome was sequenced to
about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a …

Importance Clinical whole-exome sequencing is increasingly used for diagnostic evaluation
of patients with suspected genetic disorders. Objective To perform clinical whole-exome …

We report here genome sequences and comparative analyses of three closely related
parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are important …