With its identification as a proto-oncogene in chronic lymphocytic leukaemia and central
role in regulating NF-κB signalling, it is perhaps not surprising that there have been an …

3D tissue culture provides a physiologically relevant and genetically tractable system for
studying normal and malignant human tissues. Despite this, gene-silencing studies using …

To decrease bowel cancer incidence and improve survival, we need to understand the
mechanisms that drive tumorigenesis. Recently, B-cell lymphoma 3 (BCL-3; a key regulator of NF-…

Aspirin is a well-known nonsteroidal anti-inflammatory drug (NSAID) that has a recognized
role in cancer prevention as well as evidence to support its use as an adjuvant for cancer …

Background Type 2 diabetes is associated with higher risk of several cancer types. However,
the biological intermediates driving this relationship are not fully understood. As novel …

Background Most colorectal cancers (CRC) arise sporadically from precursor lesions: colonic
polyps. Polyp resection prevents progression to CRC. Risk of future polyps is proportional …

Background: LGR5 serves as a co-receptor for Wnt/β-catenin signalling and marks normal
intestinal stem cells; however, its role in colorectal cancer (CRC) remains controversial. LGR5…

Background To support proliferation and survival within a challenging microenvironment,
cancer cells must reprogramme their metabolism. As such, targeting cancer cell metabolism is …

This paper describes ongoing research work to build a network management system from
autonomous software agents, using the BT Zeus Agent Building Toolkit. The network specific …

Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign
adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells …