The conserved family of Wnt signaling molecules mediates various developmental processes
including governing cell fate, proliferation, and polarity. The diverse developmental …

Cell invasion through the basement membrane (BM) occurs during normal embryonic
development and is a fundamental feature of cancer metastasis. The underlying cellular and …

Long-held ideas regarding the evolutionary relationships among animals have recently been
upended by sometimes controversial hypotheses based largely on insights from molecular …

INTRODUCTION Organisms live by means of the complex, dynamic, three-dimensional (3D)
interplay between millions of components, from the molecular to the multicellular. …

Nematostella vectensis, an anthozoan cnidarian, whose genome has been sequenced and
is suitable for developmental and ecological studies, has a complex neural morphology that …

Background Hox genes were critical to many morphological innovations of bilaterian
animals. However, early Hox evolution remains obscure. Phylogenetic, developmental, and …

Nearly all metazoans show signs of bilaterality, yet it is believed the bilaterians arose from
radially symmetric forms hundreds of millions of years ago. Cnidarians (corals, sea anemones…

Despite critical roles in development and cancer, the mechanisms that specify invasive
cellular behavior are poorly understood. Through a screen of transcription factors in …

The auxin-inducible degron (AID) system has emerged as a powerful tool to conditionally
deplete proteins in a range of organisms and cell types. Here, we describe a toolkit to augment …

Matrix metalloproteinases (MMPs) are associated with decreased patient prognosis but have
failed as anti-invasive drug targets despite promoting cancer cell invasion. Through time-…