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… Sherwood; An active role for basement membrane assembly and modification in tissue
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Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By developing a …

Cell-cell interactions are thought to regulate the differential specification of secondary
mesenchyme cells (SMCs) and endoderm in the sea urchin embryo. The molecular bases of these …

Cell invasion through basement membranes is crucial during morphogenesis and cancer
metastasis. Here, we genetically dissect this process during anchor-cell invasion into the …

An understanding of cell-invasive behavior has been limited by the lack of in vivo models
where this activity can be clearly visualized and manipulated. We show that a single cell in the …

Despite critical roles in development and cancer, the mechanisms that specify invasive
cellular behavior are poorly understood. Through a screen of transcription factors in …

… Sherwood; The netrin receptor DCC focuses invadopodia-driven basement membrane
transmigration in vivo. J Cell Biol 10 June 2013; 201 (6): 903–913. doi: https://doi.org/10.1083/jcb.…