The advent of genomics has led to the identification of specific “driver” mutations in oncogenic
kinases, and the development of targeted small molecule inhibitors to block their tumor-…

Posttranslational histone modifications are important for gene regulation, yet the mode of
propagation and the contribution to heritable gene expression states remains controversial. To …

One strategy for combating cancer-drug resistance is to deploy rational polytherapy up front
that suppresses the survival and emergence of resistant tumor cells. Here we demonstrate in …

Although oncogene-targeted therapy often elicits profound initial tumor responses in patients,
responses are generally incomplete because some tumor cells survive initial therapy as …

Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such
as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively …

Recent studies have indicated that nucleosome turnover is rapid, occurring several times
per cell cycle. To access the effect of nucleosome turnover on the epigenetic landscape, we …

ROS1 fusion oncoproteins exhibit differential activation of MAPK signaling according to
subcellular localization, with ROS1 fusions localized to endosomes, the strongest activators of …

Piezoelectrically generated lithotripter shocks were shown to produce premature ventricular
contractions of the frog heart. Anesthetized grass frogs, Rana pipiens, were studied …

ABS>The heat capacity, thermal expansion, and thermal conductivity were measured for
thirteen different refractory materials, including ATJ graphite, tungsten, four nitrides, two borides…

We have examined the influence of chronic in vivo alterations of thyroxine levels on the
electrophysiological and mechanical properties of rabbit ventricular papillary muscles measured …