Cation-π interactions arise as a result of strong attractive forces between positively charged
entities and the π-electron cloud of aromatic groups. The physicochemical characteristics of …

The ATP-binding cassette (ABC) transporter superfamily includes many proteins of clinical
relevance, with genes expressed in all domains of life. Although most members use the …

Impaired chloride transport affects diverse processes ranging from neuron excitability to
water secretion, which underlie epilepsy and cystic fibrosis, respectively. The ability to image …

INTRODUCTION Members of the voltage-gated sodium (Na v ) channel family are critical
contributors to electrical signaling. Accordingly, they are targets of drugs, toxins, and mutations …

Premature termination codons (PTCs) are responsible for 10–15% of all inherited disease.
PTC suppression during translation offers a promising approach to treat a variety of genetic …

Cystic fibrosis-related diabetes is the most common comorbidity associated with cystic fibrosis
(CF) and correlates with increased rates of lung function decline. Because glucose is a …

The aromatic side-chains of phenylalanine, tyrosine, and tryptophan interact with their
environments via both hydrophobic and electrostatic interactions. Determining the extent to which …

The essential transmembrane Na + and K + gradients in animal cells are established by the
Na + /K + pump, a P-type ATPase that exports three Na + and imports two K + per ATP …

… Infield … Infield … DT Infield was involved in designing experiments and contributed to
manuscript preparation. C. Kuang and CZ Prince made all of the DNA constructs. …

Neisseria meningitidis is a leading cause of bacterial meningitis and sepsis associated with
a high mortality rate. Capsular polysaccharides (CPSs) are a major virulence factor and form …