User profiles for D. V. Serreze
 | David SerrezeProfessor, The Jackson Laboratory Verified email at jax.org Cited by 15497 |
[HTML][HTML] Single domain antibodies: promising experimental and therapeutic tools in infection and immunity
…, O Boyer, M Seman, A Licea, DV Serreze… - Medical microbiology …, 2009 - Springer
Antibodies are important tools for experimental research and medical applications. Most
antibodies are composed of two heavy and two light chains. Both chains contribute to the …
antibodies are composed of two heavy and two light chains. Both chains contribute to the …
Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease
For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune …
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune …
B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new" speed congenic" stock of NOD. Ig mu null mice.
DV Serreze, HD Chapman, DS Varnum… - The Journal of …, 1996 - rupress.org
The T lymphocytes mediating autoimmune destruction of pancreatic beta cells in the
nonobese diabetic (NOD) mouse model of insulin-dependent diabetes mellitus (IDDM) may be …
nonobese diabetic (NOD) mouse model of insulin-dependent diabetes mellitus (IDDM) may be …
Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.
…, D Zipris, AH Lazarus, DV Serreze… - The Journal of …, 1993 - rupress.org
Beginning at the time of insulitis (7 wk of age), CD4+ and CD8+ mature thymocytes from
nonobese diabetic (NOD) mice exhibit a proliferative unresponsiveness in vitro after T cell …
nonobese diabetic (NOD) mice exhibit a proliferative unresponsiveness in vitro after T cell …
B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice
DV Serreze, SA Fleming, HD Chapman… - The Journal of …, 1998 - journals.aai.org
Nonobese diabetic (NOD) mice genetically deficient in B lymphocytes (NOD. Igμ null) are
resistant to T cell-mediated autoimmune insulin-dependent diabetes mellitus (IDDM). Ig …
resistant to T cell-mediated autoimmune insulin-dependent diabetes mellitus (IDDM). Ig …
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
…, C Shawber, CR Norton, DV Serreze… - Genes & …, 1998 - genesdev.cshlp.org
The Notch signaling pathway is a conserved intercellular signaling mechanism that is
essential for proper embryonic development in numerous metazoan organisms. We have …
essential for proper embryonic development in numerous metazoan organisms. We have …
Genetic and pathogenic basis of autoimmune diabetes in NOD mice
DV Serreze, EH Leiter - Current opinion in immunology, 1994 - Elsevier
Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune
insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this …
insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this …
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
…, SL Chen, R Rosa, AM Cumiskey, DV Serreze… - Nature …, 2007 - nature.com
Autoimmune diseases are thought to result from imbalances in normal immune physiology
and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles …
and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles …
Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
…, JA Caldwell, DV Serreze… - Proceedings of the …, 2003 - National Acad Sciences
Type 1 diabetes is an autoimmune disease in which autoreactive T cells attack and destroy
the insulin-producing pancreatic β cells. CD8 + T cells are essential for this β cell destruction, …
the insulin-producing pancreatic β cells. CD8 + T cells are essential for this β cell destruction, …
Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant
DV Serreze, EH Leiter, GJ Christianson, D Greiner… - Diabetes, 1994 - Am Diabetes Assoc
… DV SERREZE AND ASSOCIATES … Leiter EH, Serreze DV: Antigen-presenting cells and
the immunogenetics of autoimmune diabetes in NOD mice. Reg Immunol 4:263-73, 1992 …
the immunogenetics of autoimmune diabetes in NOD mice. Reg Immunol 4:263-73, 1992 …