User profiles for D. W. Lambert

Daniel W Lambert

University of Sheffield
Verified email at sheffield.ac.uk
Cited by 4651

Challenges and directions in studying cell–cell communication by extracellular vesicles

…, DRF Carter, A Clayton, DW Lambert… - … Reviews Molecular Cell …, 2022 - nature.com
Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular
communication. They have important roles in numerous physiological and pathological …

Membrane-associated zinc peptidase families: comparing ACE and ACE2

JL Guy, DW Lambert, FJ Warner, NM Hooper… - … et Biophysica Acta (BBA …, 2005 - Elsevier
… has been detected in urine (DW Lambert, GI Rice, NM Hooper and … is distinct from that of
ACE (DW Lambert, NM Hooper and AJ … and cytosolic domains (DW Lambert, K. Pogson and AJ …

Angiotensin-converting enzyme 2 and new insights into the renin–angiotensin system

DW Lambert, NM Hooper, AJ Turner - Biochemical pharmacology, 2008 - Elsevier
Components of the renin–angiotensin system are well established targets for pharmacological
intervention in a variety of disorders. Many such therapies abrogate the effects of the …

[HTML][HTML] Tumor necrosis factor-α convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) …

DW Lambert, M Yarski, FJ Warner, P Thornhill… - Journal of Biological …, 2005 - ASBMB
Angiotensin-converting enzyme-2 (ACE2) is a critical regulator of heart function and a cellular
receptor for the causative agent of severe-acute respiratory syndrome (SARS), SARS-CoV …

Substrate‐induced regulation of the human colonic monocarboxylate transporter, MCT1

MA Cuff, DW Lambert… - The Journal of …, 2002 - Wiley Online Library
Butyrate is the principal source of energy for colonic epithelial cells, and has profound
effects on their proliferation, differentiation and apoptosis. Transport of butyrate across the …

[HTML][HTML] Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells

FJ Warner, RA Lew, AI Smith, DW Lambert… - Journal of Biological …, 2005 - ASBMB
Angiotensin-converting enzyme-2 (ACE2) is a homologue of angiotensin-I converting enzyme
(ACE), the central enzyme of the renin-angiotensin system (RAS). ACE2 is abundant in …

[HTML][HTML] MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1

…, AV Jones, EE Hinsley, SA Whawell, DW Lambert - FEBS letters, 2011 - Elsevier
Alterations in the levels of molecules which interact with the extracellular matrix, such as
integrins, are associated with invasion of oral squamous cell carcinomas (OSCC). The …

Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress

NE Clarke, ND Belyaev, DW Lambert… - Clinical Science, 2014 - portlandpress.com
ACE2 (angiotensin-converting enzyme 2) counterbalances the actions of ACE (angiotensin-converting
enzyme) by metabolizing its catalytic product, the vasoactive and fibrogenic …

[HTML][HTML] Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain

DW Lambert, NE Clarke, NM Hooper, AJ Turner - FEBS letters, 2008 - Elsevier
Angiotensin-converting enzyme-2 (ACE2) is a regulatory protein of the renin–angiotensin
system (RAS) and a receptor for the causative agent of severe-acute respiratory syndrome (…

[HTML][HTML] Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy

DW Lambert, IS Wood, A Ellis… - British journal of …, 2002 - nature.com
Healthy colonocytes derive 60–70% of their energy supply from short-chain fatty acids,
particularly butyrate. Butyrate has profound effects on differentiation, proliferation and apoptosis …