… The growth rate of mutant discs continues to lag such that, at the normal time of pupation (∼5
d after egg laying), their numbers are only about one-third those of wild type. However, …

New developments in the treatment and management of phenylketonuria (PKU) as well as
advances in molecular testing have emerged since the National Institutes of Health 2000 …

… D: Representation of the temporal overlap of critical events relating to follicle cell … to delineate
the apical and basolateral membrane domains (Bilder et al., 2003; Tanentzapf and Tepass, …

… 3, C and D) contained 4.7 times as many cells as wild-type (… Confocal microscope sections
of WT (A andB) and scrib (C and D) … High-magnification images of WT (E) and scrib (F) discs …

… d, Similar image of a scrib … image of stage-15 wild-type embryonic epidermis stained for
α-Spectrin. Note the regular columnar monolayer organization of the epithelium. f, Similar image …

… cross-section images are shown below. d–i, Confocal microscopy images of wild-type (d, g),
crb … High-magnification cross-section images are shown below. Cells in crb H99 and dlg M/Z …

… Images are representative of more than 20 discs for each genotype. d–f, EAD and adult eye
morphology from animals with GFP-labelled control (e, f), atg13 −/− (e) or atg14 −/− (f) clones…

… observed (Figure 3D). The existence of separated, multicell twin spots (Figure 3D left) is …
Contiguous twin spots (Figure 3D, right) generally contained more cells than separated twin …

… (D–F) Polarity defects in A3 imaginal disc cells (marked by the absence of GFP). aPKC (blue
in [D]… the absence of red pigment in bright field images, demonstrating the absence of vps25 …

… Bilder and McMahon have served as consultants to BioMarin. Dr. McMahon has a patent
with Lineagen. Tara Buck, MD and Deborah Bilder, MD had full access to all the data in the …