Determining protein levels in each tissue and how they compare with RNA levels is important
for understanding human biology and disease as well as regulatory processes that control …

Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …

Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for interpreting
disease-associated variants, and context-specific QTLs show particular relevance for …

Precise interpretation of the effects of rare protein-truncating variants (PTVs) is important for
accurate determination of variant impact. Current methods for assessing the ability of PTVs …

Multi-omics datasets are becoming more common, necessitating better integration methods
to realize their revolutionary potential. Here, we introduce multi-set correlation and factor …

Complex traits and diseases can be influenced by both genetics and environment. However,
given the large number of environmental stimuli and power challenges for gene-by-…

Long non-coding RNA (lncRNA) genes are known to have diverse impacts on gene regulation.
However, it is still a major challenge to distinguish functional lncRNAs from those that are …

This thesis constitutes an exhaustive analysis of peripheral blood gene expression across a
diverse set of neurodegenerative disease. The first manuscript included in the thesis …

… Clusters C7–monocyte and C8–DC are also included for visual reference. e, Calculation
of the proportion of MG bearing a CHIP mutation in each sample. Error bars depict the …