User profiles for D. C. Nachun
Daniel NachunStanford University Verified email at stanford.edu Cited by 966 |
[PDF][PDF] A quantitative proteome map of the human body
Determining protein levels in each tissue and how they compare with RNA levels is important
for understanding human biology and disease as well as regulatory processes that control …
for understanding human biology and disease as well as regulatory processes that control …
[PDF][PDF] Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease
OM de Goede, DC Nachun, NM Ferraro… - Cell, 2021 - cell.com
Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …
Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects
Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for interpreting
disease-associated variants, and context-specific QTLs show particular relevance for …
disease-associated variants, and context-specific QTLs show particular relevance for …
[PDF][PDF] Nonsense-mediated decay is highly stable across individuals and tissues
Precise interpretation of the effects of rare protein-truncating variants (PTVs) is important for
accurate determination of variant impact. Current methods for assessing the ability of PTVs …
accurate determination of variant impact. Current methods for assessing the ability of PTVs …
[PDF][PDF] Multiset correlation and factor analysis enables exploration of multi-omics data
Multi-omics datasets are becoming more common, necessitating better integration methods
to realize their revolutionary potential. Here, we introduce multi-set correlation and factor …
to realize their revolutionary potential. Here, we introduce multi-set correlation and factor …
[PDF][PDF] An integrated approach to identify environmental modulators of genetic risk factors for complex traits
Complex traits and diseases can be influenced by both genetics and environment. However,
given the large number of environmental stimuli and power challenges for gene-by-…
given the large number of environmental stimuli and power challenges for gene-by-…
Long non-coding RNA gene regulation and trait associations across human tissues
Long non-coding RNA (lncRNA) genes are known to have diverse impacts on gene regulation.
However, it is still a major challenge to distinguish functional lncRNAs from those that are …
However, it is still a major challenge to distinguish functional lncRNAs from those that are …
[BOOK][B] Peripheral inflammation in neurodegenerative diseases
DC Nachun - 2018 - search.proquest.com
This thesis constitutes an exhaustive analysis of peripheral blood gene expression across a
diverse set of neurodegenerative disease. The first manuscript included in the thesis …
diverse set of neurodegenerative disease. The first manuscript included in the thesis …
[HTML][HTML] Clonal hematopoiesis is associated with protection from Alzheimer's disease
…, S Wirth, L Ma, MR Chrostek, H Ahmad, D Nachun… - Nature Medicine, 2023 - nature.com
… Clusters C7–monocyte and C8–DC are also included for visual reference. e, Calculation
of the proportion of MG bearing a CHIP mutation in each sample. Error bars depict the …
of the proportion of MG bearing a CHIP mutation in each sample. Error bars depict the …