The intestinal epithelium is a structured organ composed of crypts harboring Lgr5+ stem
cells, and villi harboring differentiated cells. Spatial transcriptomics have demonstrated …

10.7554/eLife.36739.001 Cell division is essential to expand, shape, and replenish epithelia.
In the adult small intestine, cells from a common progenitor intermix with other lineages, …

The classical model of tissue renewal posits that small numbers of quiescent stem cells (SCs)
give rise to proliferating transit-amplifying cells before terminal differentiation. However, …

Niche-derived factors regulate tissue stem cells, but apart from the mechanosensory
pathways, the effect of niche geometry is not well understood. We used organoids and …

During homeostasis, the colonic epithelium is replenished every 3–5 days by rapidly cycling
Lgr5 + stem cells. However, various insults can lead to depletion of Lgr5 + stem cells, and …

The integrity of taste buds is intimately dependent on an intact gustatory innervation, yet the
molecular nature of this dependency is unknown. Here, we show that differentiation of new …

Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration
after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct …

Defining the mechanisms that generate specialized cell types and coordinate their functions
is critical for understanding organ development and renewal. New tools and discoveries are …

The gastrointestinal tract relies on the production, maturation, and transit of mucin to protect
against pathogens and to lubricate the epithelial lining. Although the molecular and cellular …

Adult tongue epithelium is continuously renewed from epithelial progenitor cells, a process
that requires hedgehog (HH) signaling. In mice, pharmacological inhibition of the HH …