Immune cell function is critically dependent on precise control over transcriptional output
from the genome. In this respect, integration of environmental signals that regulate gene …

We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional
(3D) genome architectures at the chromosome scale. Each type appears and …

Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 (…

While Mediator plays a key role in eukaryotic transcription, little is known about its mechanism
of action. This study combines CRISPR-Cas9 genetic screens, degron assays, Hi-C, and …

The molecular mechanisms governing orderly shutdown and retraction of CD4 + type 1
helper T (T H 1) cell responses remain poorly understood. Here we show that complement …

INTRODUCTION Studies of monogenic diseases have uncovered the importance of
immune pathways in human tissue-specific immunity and antimicrobial defense. In particular, …

During chronic infection and cancer, a self-renewing CD8 + T cell subset maintains long-term
immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8 + T …

The eye lens consists of a layer of epithelial cells that overlay a series of differentiating fiber
cells that upon maturation lose their mitochondria, nuclei and other organelles. Lens …

Systemic candidiasis is a common, high-mortality, nosocomial fungal infection. Unexpectedly,
it has emerged as a complication of anti-complement C5-targeted monoclonal antibody …

Intrinsic complement C3 activity is integral to human T helper type 1 (Th1) and cytotoxic T cell
responses. Increased or decreased intracellular C3 results in autoimmunity and infections, …