User profiles for D. Chauss
Daniel ChaussNIDDK Immunoregulation Section Verified email at nih.gov Cited by 1561 |
[HTML][HTML] Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations
Immune cell function is critically dependent on precise control over transcriptional output
from the genome. In this respect, integration of environmental signals that regulate gene …
from the genome. In this respect, integration of environmental signals that regulate gene …
3D genomics across the tree of life reveals condensin II as a determinant of architecture type
We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional
(3D) genome architectures at the chromosome scale. Each type appears and …
(3D) genome architectures at the chromosome scale. Each type appears and …
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 (…
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 (…
[PDF][PDF] A pliable mediator acts as a functional rather than an architectural bridge between promoters and enhancers
While Mediator plays a key role in eukaryotic transcription, little is known about its mechanism
of action. This study combines CRISPR-Cas9 genetic screens, degron assays, Hi-C, and …
of action. This study combines CRISPR-Cas9 genetic screens, degron assays, Hi-C, and …
[HTML][HTML] Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
The molecular mechanisms governing orderly shutdown and retraction of CD4 + type 1
helper T (T H 1) cell responses remain poorly understood. Here we show that complement …
helper T (T H 1) cell responses remain poorly understood. Here we show that complement …
Aberrant type 1 immunity drives susceptibility to mucosal fungal infections
INTRODUCTION Studies of monogenic diseases have uncovered the importance of
immune pathways in human tissue-specific immunity and antimicrobial defense. In particular, …
immune pathways in human tissue-specific immunity and antimicrobial defense. In particular, …
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells
During chronic infection and cancer, a self-renewing CD8 + T cell subset maintains long-term
immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8 + T …
immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8 + T …
Autophagy and mitophagy participate in ocular lens organelle degradation
The eye lens consists of a layer of epithelial cells that overlay a series of differentiating fiber
cells that upon maturation lose their mitochondria, nuclei and other organelles. Lens …
cells that upon maturation lose their mitochondria, nuclei and other organelles. Lens …
C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection
Systemic candidiasis is a common, high-mortality, nosocomial fungal infection. Unexpectedly,
it has emerged as a complication of anti-complement C5-targeted monoclonal antibody …
it has emerged as a complication of anti-complement C5-targeted monoclonal antibody …
[PDF][PDF] Diapedesis-induced integrin signaling via LFA-1 facilitates tissue immunity by inducing intrinsic complement C3 expression in immune cells
Intrinsic complement C3 activity is integral to human T helper type 1 (Th1) and cytotoxic T cell
responses. Increased or decreased intracellular C3 results in autoimmunity and infections, …
responses. Increased or decreased intracellular C3 results in autoimmunity and infections, …