… Friedman, John D. Diller, Betsy M. Ferguson, Sarah VM Nyland, Bonita J. … David
Cobrinik, Myung-Ho Lee, Gregory Hannon, George Mulligan, Roderick T. Bronson …

… pRB phosphorylation was recognized to be directed by mitogenic signals that converge on
the cell cycle machinery, composed of D cyclins acting with Cdk4 or Cdk6 in early and mid-G1…

Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …

… presumably owing to its weak cross-reactivity with pl07 (D. Cobrinik, unpubl.). These findings
indicated that pi07 replaced pl30 as the major E2F-associated species in pl30~'~ MEFs, …

The activity of the E2F transcription factor is controlled by physical association with the
retinoblastoma protein (pRB) and two related proteins, p107 and p130. The pRB family members …

… The ability of the adenovirus E1A protein to dissociate mouse fibroblast Go/ G1 E2F complexes
(Mudryj et al. 1991; D. Cobrinik, data not shown) suggested that E1A binds to the Go/G1 …

… (D). Labels indicate positions of cone (“C”), bipolar (“B”), Müller (“M”), and amacrine (“A”)
cells, and an antibody-independent signal (“ ∗ ”). Note that the P12 cone precursors in (D) are …

Identifying the spectrum of genetic alterations that cooperate with critical oncogenes to
promote transformation provides a foundation for understanding the diversity of clinical …

… d–f, Co-staining of Ki67 with RXRγ and CRX at 14 days (d), with cone arrestin and CRX at
14 days (e), or with L/M-opsin and CRX at 23 days (f) after transduction with shRB1-733 or a …

… Regions C and D are reported to be necessary for the heterodimerization of E2F-1 with DP-1
(29). Region C is likely to be involved in this association since it shows a conserved heptad …