User profiles for D. Drucker

Daniel J. Drucker

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto
Verified email at lunenfeld.ca
Cited by 88842

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

DJ Drucker, MA Nauck - The Lancet, 2006 - thelancet.com
Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that stimulates insulin and
suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite and food …

[PDF][PDF] The biology of incretin hormones

DJ Drucker - Cell metabolism, 2006 - cell.com
… Within islets, the GLP-1R is predominantly localized to b cells, although GLP-1R expression
on islet a and d cells has also been reported. Although numerous studies allege the …

Glucagon-like peptides

DJ Drucker - Diabetes, 1998 - Am Diabetes Assoc
Proglucagon contains the sequence of two glucagonlike peptides, GLP-1 and GLP-2, secreted
from enteroendocrine cells of the small and large intestine. GLP-1 lowers blood glucose …

A definition of stable inelastic material

DC Drucker - 1959 - asmedigitalcollection.asme.org
The definitions given previously for work-hardening and perfect plasticity are broadened to
cover viscous effects. As before, the system considered is isothermal and includes both the …

Biological actions and therapeutic potential of the glucagon-like peptides

DJ Drucker - Gastroenterology, 2002 - Elsevier
The glucagon-like peptides (GLP-1 and GLP-2) are proglucagon-derived peptides cosecreted
from gut endocrine cells in response to nutrient ingestion. GLP-1 acts as an incretin to …

[PDF][PDF] Mechanisms of action and therapeutic application of glucagon-like peptide-1

DJ Drucker - Cell metabolism, 2018 - cell.com
… GLP-1 acts through the GLP-1 receptor (GLP-1R) expressed on islet b cells and d cells to
control insulin and somatostatin (SMS) secretion, respectively. SMS in turn inhibits glucagon …

Minireview: the glucagon-like peptides

DJ Drucker - Endocrinology, 2001 - academic.oup.com
… of GLP-2 to rats following major small bowel resection enhanced endogenous intestinal
adaptation, with significant increases in mucosal weight, villus height, sucrase activity, and d-…

Biology of incretins: GLP-1 and GIP

LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier
This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …

[PDF][PDF] The cardiovascular biology of glucagon-like peptide-1

DJ Drucker - Cell metabolism, 2016 - cell.com
Glucagon-like peptide-1, produced predominantly in enteroendocrine cells, controls
glucose metabolism and energy homeostasis through regulation of islet hormone secretion, …

[HTML][HTML] The role of gut hormones in glucose homeostasis

DJ Drucker - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
The gastrointestinal tract has a crucial role in the control of energy homeostasis through its
role in the digestion, absorption, and assimilation of ingested nutrients. Furthermore, signals …