Eicosanoids have been implicated in a vast number of devastating inflammatory conditions,
including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different …

… deuterated species (PGD 2 and d 4 -PGD 2 ), or 2) matching the metabolite with an internal
standard that has a similar chemical structure and retention time (PGJ 2 and d 4 -15d-PGJ 2 )…

… (D) WT mice displayed significant thermal hyposensitivity compared to Tlr4 −/− mice only
on day 3. Each time point represents mean ± SEM (n = 9 mice/group), ∗∗∗ P < .001 by …

… We report here the development of a high affinity (K D = 200 nM) inhibitor from a low affinity
fragment hit with supporting biochemical and structural data showing these molecules bind …

Peripheral inflammation initiates changes in spinal nociceptive processing leading to
hyperalgesia. Previously, we demonstrated that among 102 lipid species detected by LC-MS/MS …

… rosiglitzone (Ro) (20 mg per kg per day for 5 d) or maintained on a control diet (n = 10
mice per … (d) Effect of genotype and rosiglitzone treatment on accumulation of Alcian blue–positive …

Eicosanoid metabolism differs in profile and quantity between macrophages of different
tissue origin and method of elicitation, as well as between primary and immortalized …

10.7554/eLife.48120.001 Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the
primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. …

Cardiolipin, a major component of mitochondria, is critical for mitochondrial functioning
including the regulation of cytochrome c release during apoptosis and proper electron transport. …

… old (as much as much as 500 million years of co-evolution),17 and interesting in that cGAS
is a low-activity enzyme while STING is a particularly avid binder of the cGAS product (K d ∼…