Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …

… Class II PI3K genes have been cloned from humans and mice as well as from D. … This lipid
can be generated from phosphatidylcholine by phospholipase D and from diacylglycerol (DAG…

The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …

The immunosuppressive agents cyclosporin A (CsA) and FK 506 bind to distinct families of
intracellular proteins (immunophilins) termed cyclophilins and FK 506-binding proteins (…

… 1D) suggests that the differences observed in T and B cell function cannot be explained by
differential expression of this adapter isoform. Treatment with Ly294002 only slightly inhibited …

… We killed the mice 8 d after immunization for immune assessment. We detected serum
immunoglobulin by ELISA using standard procedures that are further detailed in the …

The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction
network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. …

The avian sarcoma virus 16 (ASV 16) is a retrovirus that induces hemangiosarcomas in
chickens. Analysis of the ASV 16 genome revealed that it encodes an oncogene that is derived …

… Lane, D. Fruman, submitted manuscript). It seems reasonable to propose that p85α and
p85β (and perhaps p50α, which is also expressed in T cells) have redundant functions in …

Tec family non-receptor tyrosine kinases have been implicated in signal transduction events
initiated by cell surface receptors from a broad range of cell types, including an essential …