User profiles for D. Gackowski
 | Daniel GackowskiNicolaus Copernicus University (UMK), Torun, Poland Verified email at cm.umk.pl Cited by 6115 |
Oxidative DNA damage: assessment of the role in carcinogenesis, atherosclerosis, and acquired immunodeficiency syndrome
… Therefore, in our study, the urine samples (24 h output) were collected after 3 d nucleic
acid-free diet was completed and from the same persons 3–5 d after returning to a normal, …
acid-free diet was completed and from the same persons 3–5 d after returning to a normal, …
DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine
…, MD Evans, R Dove, R Rozalski, D Gackowski… - Mutation Research …, 2005 - Elsevier
The repair of oxidatively damaged DNA is integral to the maintenance of genomic stability,
and hence prevention of a wide variety of pathological conditions, such as aging, cancer and …
and hence prevention of a wide variety of pathological conditions, such as aging, cancer and …
Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?
A wide variety of oxidative DNA lesions are present in living cells. One of the best known
lesions of this type is 8-oxoguanine (8-oxoGua) which has been shown to have mutagenic …
lesions of this type is 8-oxoguanine (8-oxoGua) which has been shown to have mutagenic …
Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study
Accurate measurement of low levels of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodGuo)
in DNA is hampered by the ease with which guanine is oxidized during preparation of DNA …
in DNA is hampered by the ease with which guanine is oxidized during preparation of DNA …
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single-stranded
DNA that represent a source of genomic instability in mammalian cells 1 , 2 , 3 – 4 . …
DNA that represent a source of genomic instability in mammalian cells 1 , 2 , 3 – 4 . …
Products of oxidative DNA damage and repair as possible biomarkers of susceptibility to lung cancer
D Gackowski, E Speina, M Zielinska, J Kowalewski… - Cancer Research, 2003 - AACR
The broad spectrum of oxidative DNA damage biomarkers [urinary excretion of 8-hydroxy-2′-deoxyguanosine
(8-OH-dGuo) and 8-hydroxyguanine (8-OH-Gua)] and the level of …
(8-OH-dGuo) and 8-hydroxyguanine (8-OH-Gua)] and the level of …
Human and methodological sources of variability in the measurement of urinary 8-oxo-7, 8-dihydro-2′-deoxyguanosine
…, PB Farmer, R Rozalski, D Gackowski… - Antioxidants & redox …, 2013 - liebertpub.com
Aims: Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is a widely used biomarker
of oxidative stress. However, variability between chromatographic and ELISA methods …
of oxidative stress. However, variability between chromatographic and ELISA methods …
Toward consensus in the analysis of urinary 8-oxo-7, 8-dihydro-2′-deoxyguanosine as a noninvasive biomarker of oxidative stress
…, M Takeuchi, H Kasai, JHN Meerman, D Gackowski… - 2010 - ro.uow.edu.au
Of the DNA-derived biomarkers of oxidative stress, urinary 8-oxo-7, 8-dihydro-2′-deoxyguanosine
(8-oxodG) is the most frequently measured. However, there is significant discrepancy …
(8-oxodG) is the most frequently measured. However, there is significant discrepancy …
Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients
…, M Swoboda, E Speina, D Gackowski… - …, 2010 - academic.oup.com
Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at
which stage of the disease this phenomenon occurs. In the examined groups of patients with …
which stage of the disease this phenomenon occurs. In the examined groups of patients with …
Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia
Oxidative DNA damage may contribute to neuronal cell loss and may be involved in pathogenesis
of some neurodegenerative diseases. We assessed the broad spectrum of oxidative …
of some neurodegenerative diseases. We assessed the broad spectrum of oxidative …