The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-onset
dementia. The diagnosis of bvFTD remains challenging because of the limited accuracy …

Alzheimer’s disease (AD) is a neurodegenerative disorder accounting for over 50% of all
dementia patients and representing a leading cause of death worldwide for the global ageing …

Background and purpose Previous studies have indicated clinical benefits of a combination
of cholinesterase inhibitors (Ch EI ) and memantine over Ch EI monotherapy in Alzheimer's …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

… and D′ values equal to 1. If a perfectly tagging SNP was not available, we selected a SNP
that had equivalent MAF and the highest possible r 2 and D′ values. Estimation of r 2 and D…

… Where P i,s (D)=I i,s is the incidence rate for individuals of sex s in age group i,, P i (G=g∣D)
is the prevalence of genotype g among those who develop the disease in age category i (…

Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …