BRCA2 functions: from DNA repair to replication fork stabilization

A Fradet-Turcotte, J Sitz, D Grapton… - Endocr Relat …, 2016 - erc.bioscientifica.com
… and the formation of a D-loop, a structure that results from the invasion of the homologous
template by the RAD51-coated DNA strand. DNA synthesis and processing of the D-loop by …

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

…, A Fricot, C Chartier, O Negre, J Veiga, D Grapton… - Nature medicine, 2014 - nature.com
… 30 d of RAP-011 or PBS treatment. (j) Erythropoietin (EPO) levels measured by ELISA from
serum of thalassemic mice treated for 5, 10 or 30 d … (d) Bone marrow erythroblast number and …

SHLD 2/FAM 35A co‐operates with REV 7 to coordinate DNA double‐strand break repair pathway choice

…, M Karam, H Bagci, D Rahat, D Grapton… - The EMBO …, 2018 - embopress.org
… As expected, pathways critical for mitosis and DNA repair were enriched in our list of
REV7 partners (Fig EV1D). To further refine REV7 interactors, we intersected our data with …

Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia

S Coulon, M Dussiot, D Grapton, TT Maciel… - Nature medicine, 2011 - nature.com
… (d,e) Model summarizing the role of pIgA1 in erythropoiesis. (d) We propose that TfR1
functions as an erythroid receptor involved in the modulation of responses to Epo. In erythroid …

Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma

…, J Nadaf, S Fahiminiya, SL Arcand, DL Burk, D Grapton… - Cancer research, 2017 - AACR
RAD51D is a key player in DNA repair by homologous recombination (HR), and RAD51D
truncating variant carriers have an increased risk for ovarian cancer. However, the contribution …

Factors affecting acute skin toxicity in patients having breast irradiation after conservative surgery: a prospective study of treatment practice at the Royal Marsden …

…, TJ Powles, S Ashley, JP Glees, M Torr, D Grafton… - Clinical Oncology, 1996 - Elsevier
The results are presented of a prospective study of acute skin toxicity in 197 patients with
early stage breast cancer, who were treated by conservative surgery and postoperative …

Serum iron protects from renal postischemic injury

…, A Fricot, TT Maciel, D Grapton… - Journal of the …, 2017 - journals.lww.com
Renal transplants remain a medical challenge, because the parameters governing allograft
outcome are incompletely identified. Here, we investigated the role of serum iron in the …

[HTML][HTML] Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells

MC Gaudreau, D Grapton, A Helness, C Vadnais… - Scientific reports, 2016 - nature.com
The proliferation and survival of hematopoietic stem cells (HSCs) has to be strictly coordinated
to ensure the timely production of all blood cells. Here we report that the splice factor and …

POGZ promotes homology‐directed DNA repair in an HP1‐dependent manner

…, T Morin, B Lebeau, M Karam, H Bagci, D Grapton… - EMBO …, 2022 - embopress.org
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability
but little is known about how HP1 is controlled. Here, we show that the zinc finger protein …

[HTML][HTML] Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice

…, J Ross, H Beauchemin, R Chen, D Grapton… - Leukemia, 2019 - nature.com
D Total cell counts of splenic cells and myeloid cell counts in spleen of WT, KI, young KD (yKD),
old KD (oKD), young KO (yKO), and old KO (oKO). Orange spots mean sick mice. E …