Water quality impacts of bridge stormwater runoff from scupper drains on receiving waters: A review

AR Bakr, GY Fu, D Hedeen - Science of the Total Environment, 2020 - Elsevier
This article provides insight into the environmental significance of bridge deck stormwater
runoff from scupper drains on receiving water bodies through a review of over eighty sources …

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

I Deshpande, J Liang, D Hedeen, KJ Roberts, Y Zhang… - Nature, 2019 - nature.com
d–f, GLI-luciferase signalling assay of SMO mutations at the deep 7TM site or tunnel
entrance (d), with ablation of the hydrogen bond to Y398 (e) or with direct cholesterol–methyl-β-…

A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

…, IB Nelson, C Olivieri, J Zhang, DS Hedeen… - Nature structural & …, 2022 - nature.com
The Hedgehog (Hh) cascade is central to development, tissue homeostasis and cancer. A
pivotal step in Hh signal transduction is the activation of glioma-associated (GLI) transcription …

[HTML][HTML] Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

…, DS Hedeen, JF Zhu, JL Capener, D Klatt Shaw… - PLoS …, 2021 - journals.plos.org
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration.
Dysfunction of this cascade drives several cancers. To control expression of pathway …

[HTML][HTML] HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β

…, H Scott, J Emathinger, C Wolf, D LaJoie, D Hedeen… - Oncotarget, 2019 - ncbi.nlm.nih.gov
… (D) The serum cytokines concentration data was then assessed for correlation and
suggests that higher levels of serum OSM correlates with higher levels of serum IL-6 (Spearman …

[HTML][HTML] Co-expression of VEGF and IL-6 family cytokines is associated with decreased survival in HER2 negative breast cancer patients: subtype-specific IL-6 family …

…, A Ide, R Fox, D Greiner, D LaJoie, D Hedeen… - Translational …, 2019 - Elsevier
… helped collect and interpret data from Oncomine for Figure 1, Figure 2 and Figure S1, Figure
S2, Figure S3, and also helped write the manuscript with help from Danielle Hedeen and …

[HTML][HTML] KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion

…, MF Jin, MJ Redd, S Daetwyler, D Hedeen… - Nature …, 2021 - nature.com
Metastasis is the main cause of carcinoma-related death, yet we know little about how it initiates
due to our inability to visualize stochastic invasion events. Classical models suggest that …

[HTML][HTML] Avian species diversity and transmission of West Nile virus in Atlanta, Georgia

RS Levine, DL Hedeen, MW Hedeen, GL Hamer… - Parasites & vectors, 2017 - Springer
Background The dilution effect is the reduction in vector-borne pathogen transmission
associated with the presence of diverse potential host species, some of which are incompetent. It …

[HTML][HTML] Supersuppression: Reservoir competency and timing of mosquito host shifts combine to reduce spillover of West Nile virus

…, BJ Brosi, DL Hedeen, MW Hedeen… - The American journal …, 2016 - ncbi.nlm.nih.gov
In the eastern United States, human cases of West Nile virus (WNV) result from spillover from
urban epizootic transmission between passerine birds and Culex mosquitoes. In Atlanta, …

Railway-aided dispersal of an introduced Podarcis muralis population

SE Hedeen, DL Hedeen - Herpetological Review, 1999 - search.proquest.com
The European wall lizard, Podarcis muralis, is native to southern and central Europe and
northwestern Asia Minor. Within its geographical range, the species frequents rock faces, …